A Hypothalamic Circuit Underlying the Dynamic Control of Social Homeostasis
A Hypothalamic Circuit Underlying the Dynamic Control of Social Homeostasis
Summary Social grouping increases survival in many species, including humans1,2. By contrast, social isolation generates an aversive state (loneliness) that motivates social seeking and heightens social interaction upon reunion3-5. The observed rebound in social interaction triggered by isolation suggests a homeostatic process underlying the control of social drive, similar to that observed for physiological needs such as hunger, thirst or sleep3,6. In this study, we assessed social responses in multiple mouse strains and identified the FVB/NJ line as exquisitely sensitive to social isolation. Using FVB/NJ mice, we uncovered two previously uncharacterized neuronal populations in the hypothalamic preoptic nucleus that are activated during social isolation and social rebound and that orchestrate the behavior display of social need and social satiety, respectively. We identified direct connectivity between these two populations of opposite function and with brain areas associated with social behavior, emotional state, reward, and physiological needs, and showed that animals require touch to assess the presence of others and fulfill their social need, thus revealing a brain-wide neural system underlying social homeostasis. These findings offer mechanistic insight into the nature and function of circuits controlling instinctive social need and for the understanding of healthy and diseased brain states associated with social context.
Watabe-Uchida Mitsuko、Dulac Catherine、Johnson Autumn、Tsutsui-Kimura Iku、Abdus-Saboor Ishmail、Uchida Naoshige、Liu Ding、Logeman Brandon L.、Rahman Mostafizur、Capo-Battaglia Athena、Talay Mustafa、Choi Seungwon、Pena Nicolai、Finkbeiner Samantha、Ginty David D.
Department of Molecular and Cellular Biology, Center for Brain Science, Harvard UniversityDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard UniversityDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard UniversityDepartment of Molecular and Cellular Biology, Center for Brain Science, Harvard UniversityZuckerman Mind Brain Behavior Institute, Department of Biological Sciences, Columbia UniversityDepartment of Molecular and Cellular Biology, Center for Brain Science, Harvard UniversityDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard UniversityDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard UniversityDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard UniversityDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard UniversityDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard UniversityDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical SchoolDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard UniversityDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard UniversityDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School
生理学
Watabe-Uchida Mitsuko,Dulac Catherine,Johnson Autumn,Tsutsui-Kimura Iku,Abdus-Saboor Ishmail,Uchida Naoshige,Liu Ding,Logeman Brandon L.,Rahman Mostafizur,Capo-Battaglia Athena,Talay Mustafa,Choi Seungwon,Pena Nicolai,Finkbeiner Samantha,Ginty David D..A Hypothalamic Circuit Underlying the Dynamic Control of Social Homeostasis[EB/OL].(2025-03-28)[2025-05-15].https://www.biorxiv.org/content/10.1101/2023.05.19.540391.点此复制
评论