Spinal signaling of C-fiber mediated pleasant touch in humans
Spinal signaling of C-fiber mediated pleasant touch in humans
Abstract C-tactile afferents form a distinct channel that encodes pleasant tactile stimulation. Prevailing views indicate they project, as with other unmyelinated afferents, in lamina I-spinothalamic pathways. However, we found that spinothalamic ablation in humans, whilst profoundly impairing pain, temperature and itch, had no effect on pleasant touch perception. Only discriminative touch deficits were seen. These findings preclude privileged C-tactile-lamina I-spinothalamic projections and imply integrated hedonic and discriminative spinal processing from the body.
Marshall Andrew G.、Sharma Manohar L、McGlone Francis P.、Olausson Hakan、Marley Kate
Institute of Aging and Chronic Disease, University of Liverpool||School of Natural Sciences and Psychology, Liverpool John Moores University||Department of Pain Medicine, Walton Centre NHS Foundation TrustDepartment of Pain Medicine, Walton Centre NHS Foundation TrustSchool of Natural Sciences and Psychology, Liverpool John Moores University||Institute of Psychology, Health and Society, University of LiverpoolCenter for Social and Affective Neuroscience, Link?ping University||Department of Clinical Neurophysiology, Link?ping University HospitalSpecialist Palliative Care Team, University Hospital Aintree
基础医学神经病学、精神病学生理学
Marshall Andrew G.,Sharma Manohar L,McGlone Francis P.,Olausson Hakan,Marley Kate.Spinal signaling of C-fiber mediated pleasant touch in humans[EB/OL].(2025-03-28)[2025-05-02].https://www.biorxiv.org/content/10.1101/780635.点此复制
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