ETP基因SNP/TaqIB与耐力训练对动态心功能影响的关联研究

Objective— To explore the association between CETP gene SNP/TaqIB and dynamic left ventricle structure and function of Han population in North China as well as the sensitivity to aerobic endurance training. Methods—To test the association and sensibility of the SNP/TaqIB with aerobic endurance training, One hundred and two healthy men of Han nationality in northern China were recruited to undergo aerobic training program for 18 weeks .The genotype was analyzed by PCR-RFLP, the indexes of structure and function of left ventricle (EDD, ESD, LVM, SV, EF, CO etc.) were measured before and after exercise. Results—The genotype frequencies were as follows: B1B1=36%，B1B2=42%，B2B2=22% and they were in Hardy－Weinberg equilibrium. A significant difference in SV across genotypes was observed at SNP/TaqIB, B2B2 genotype group showed significant difference with other genotype groups in SV. Characteristics of left ventricle structure such as ESD and PWD showed some difference between groups at baseline, as well as △IVSS after training. Conclusions—The result indicated that CETP gene SNP/TaqIB and dynamic left ventricle structure and function responses were related with endurance training sensitivity, B2B2 genotype might contribute to individual differences in endurance training.