Reduced Pathogenicity of the SARS-CoV-2 Omicron Variant in Hamsters
Reduced Pathogenicity of the SARS-CoV-2 Omicron Variant in Hamsters
The SARS-CoV-2 Omicron (B.1.1.529) variant has proven highly transmissible and has outcompeted the Delta variant in many regions of the world1. Early reports have also suggested that Omicron may result in less severe clinical disease in humans. Here we show that Omicron is less pathogenic than prior SARS-CoV-2 variants in Syrian golden hamsters. Infection of hamsters with the SARS-CoV-2 WA1/2020, Alpha, Beta, or Delta strains led to 4-10% weight loss by day 4 and 10-17% weight loss by day 6, as expected2,3. In contrast, infection of hamsters with two different Omicron challenge stocks did not result in any detectable weight loss, even at high challenge doses. Omicron infection still led to substantial viral replication in both the upper and lower respiratory tracts and pulmonary pathology, but with a trend towards higher viral loads in nasal turbinates and lower viral loads in lung parenchyma compared with WA1/2020 infection. These data suggest that the SARS-CoV-2 Omicron variant may result in more robust upper respiratory tract infection but less severe lower respiratory tract clinical disease compared with prior SARS-CoV-2 variants.
Kawaoka Yoshihiro、Kar Swagata、Andersen Hanne、Lewis Mark G.、McMahan Katherine、Tostanoski Lisa H.、Chung Benjamin、Halfmann Peter、Giffin Victoria、Barouch Dan H.、Siamatu Mazuba、Piedra-Mora Cesar、Suthar Mehul S.、Martinot Amanda J.
Influenza Research Institute, University of WisconsinBioqualBioqualBioqualBeth Israel Deaconess Medical CenterBeth Israel Deaconess Medical CenterBeth Israel Deaconess Medical CenterInfluenza Research Institute, University of WisconsinBeth Israel Deaconess Medical CenterBeth Israel Deaconess Medical Center||Ragon Institute of MGH, MIT, and HarvardBeth Israel Deaconess Medical CenterTufts University Cummings School of Veterinary MedicineEmory Vaccine Center, Department of Pediatrics, Emory School of MedicineTufts University Cummings School of Veterinary Medicine
医学研究方法基础医学微生物学
Kawaoka Yoshihiro,Kar Swagata,Andersen Hanne,Lewis Mark G.,McMahan Katherine,Tostanoski Lisa H.,Chung Benjamin,Halfmann Peter,Giffin Victoria,Barouch Dan H.,Siamatu Mazuba,Piedra-Mora Cesar,Suthar Mehul S.,Martinot Amanda J..Reduced Pathogenicity of the SARS-CoV-2 Omicron Variant in Hamsters[EB/OL].(2025-03-28)[2025-08-02].https://www.biorxiv.org/content/10.1101/2022.01.02.474743.点此复制
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