Prospective mapping of viral mutations that escape antibodies used to treat COVID-19
Prospective mapping of viral mutations that escape antibodies used to treat COVID-19
Antibodies are becoming a frontline therapy for SARS-CoV-2, but the risk of viral evolutionary escape remains unclear. Here we map how all mutations to SARS-CoV-2’s receptor-binding domain (RBD) affect binding by the antibodies in Regeneron’s REGN-COV2 cocktail and Eli Lilly’s LY-CoV016. These complete maps uncover a single amino-acid mutation that fully escapes the REGN-COV2 cocktail, which consists of two antibodies targeting distinct structural epitopes. The maps also identify viral mutations that are selected in a persistently infected patient treated with REGN-COV2, as well as in lab viral escape selections. Finally, the maps reveal that mutations escaping each individual antibody are already present in circulating SARS-CoV-2 strains. Overall, these complete escape maps enable immediate interpretation of the consequences of mutations observed during viral surveillance.
Bloom Jesse D.、Choudhary Manish C.、Dingens Adam S.、Starr Tyler N.、Addetia Amin、Hannon William W.、Li Jonathan Z.、Greaney Allison J.
Basic Sciences and Computational Biology, Fred Hutchinson Cancer Research Center||Department of Genome Sciences, University of Washington||Howard Hughes Medical InstituteBrigham and Women?ˉs Hospital, Harvard Medical SchoolBasic Sciences and Computational Biology, Fred Hutchinson Cancer Research CenterBasic Sciences and Computational Biology, Fred Hutchinson Cancer Research CenterBasic Sciences and Computational Biology, Fred Hutchinson Cancer Research Center||Molecular and Cellular Biology Graduate Program, University of WashingtonBasic Sciences and Computational Biology, Fred Hutchinson Cancer Research Center||Molecular and Cellular Biology Graduate Program, University of WashingtonBrigham and Women?ˉs Hospital, Harvard Medical SchoolBasic Sciences and Computational Biology, Fred Hutchinson Cancer Research Center||Department of Genome Sciences, University of Washington||Medical Scientist Training Program, University of Washington
医药卫生理论医学研究方法生物科学研究方法、生物科学研究技术
Bloom Jesse D.,Choudhary Manish C.,Dingens Adam S.,Starr Tyler N.,Addetia Amin,Hannon William W.,Li Jonathan Z.,Greaney Allison J..Prospective mapping of viral mutations that escape antibodies used to treat COVID-19[EB/OL].(2025-03-28)[2025-06-13].https://www.biorxiv.org/content/10.1101/2020.11.30.405472.点此复制
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