Identification of novel human derived influenza viruses in pigs with zoonotic potential
Identification of novel human derived influenza viruses in pigs with zoonotic potential
Abstract In 2009, a novel swine influenza A virus (IAV) emerged causing a global pandemic that highlighted the role of swine as a reservoir. To date, there is limited information about swine IAV circulating in Latin America. We identified two swine H1N2 and one divergent swine H3N2 viruses that co-circulated in Chilean swine together with the 2009 H1N1 pandemic strain (A(H1N1)pdm09). Phylogenetic analysis revealed several human-to-swine IAV introductions occurring as early as the mid-1980s, and since 2009, several introductions of the A(H1N1)pdm09 strain. Antigenic cartography confirmed that these viruses were antigenically unique and identified drifted variants within the clusters. Human sera from the Chilean general population showed an age dependent mid to low-level antibody mediated protection against swine H1N2 and A(H1N1)pdm09-like viruses and a poor protection against the swine H3N2 virus, highlighting the zoonotic potential of this strain. Our results underscore the epidemiological importance of studying swine IAV in Latin America for epidemic and pandemic preparedness.
Saavedra Marco、Garc¨aa-Salum Tamara、Rathnasinghe Raveen、Tapia Karla、Bucarey Sergio、Jang Yunho、Medina Rafael A.、Torremorell Montserrat、Tapia Rodrigo、Garc¨aa Victoria、Wentworth David、Barriga Gonzalo、Mena Juan、Brito B¨￠rbara、Neira V¨actor
Departamento de Enfermedades Infecciosas e Inmunolog¨aa Pedi¨￠trica, Escuela de Medicina, Pontificia Universidad Cat¨?lica de ChileDepartamento de Enfermedades Infecciosas e Inmunolog¨aa Pedi¨￠trica, Escuela de Medicina, Pontificia Universidad Cat¨?lica de ChileDepartamento de Enfermedades Infecciosas e Inmunolog¨aa Pedi¨￠trica, Escuela de Medicina, Pontificia Universidad Cat¨?lica de ChileDepartamento de Enfermedades Infecciosas e Inmunolog¨aa Pedi¨￠trica, Escuela de Medicina, Pontificia Universidad Cat¨?lica de ChileDepartamento de Medicina Preventiva, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de ChileInfluenza Division, Centers for Disease Control and Prevention (CDC), AtlantaDepartamento de Enfermedades Infecciosas e Inmunolog¨aa Pedi¨￠trica, Escuela de Medicina, Pontificia Universidad Cat¨?lica de Chile||Department of Microbiology, Icahn School of Medicine at Mount SinaiVeterinary Population Medicine, College of Veterinary Medicine, University of MinnesotaDepartamento de Medicina Preventiva, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de ChileDepartamento de Medicina Preventiva, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de ChileInfluenza Division, Centers for Disease Control and Prevention (CDC), AtlantaDepartamento de Enfermedades Infecciosas e Inmunolog¨aa Pedi¨￠trica, Escuela de Medicina, Pontificia Universidad Cat¨?lica de ChileDepartamento de Medicina Preventiva, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de ChileDepartamento de Medicina Preventiva, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile||Departamento de Enfermedades Infecciosas e Inmunolog¨aa Pedi¨￠trica, Escuela de Medicina, Pontificia Universidad Cat¨?lica de Chile||The ithree Institute, University of Technology SydneyDepartamento de Medicina Preventiva, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile
医药卫生理论医学研究方法预防医学
Saavedra Marco,Garc¨aa-Salum Tamara,Rathnasinghe Raveen,Tapia Karla,Bucarey Sergio,Jang Yunho,Medina Rafael A.,Torremorell Montserrat,Tapia Rodrigo,Garc¨aa Victoria,Wentworth David,Barriga Gonzalo,Mena Juan,Brito B¨￠rbara,Neira V¨actor.Identification of novel human derived influenza viruses in pigs with zoonotic potential[EB/OL].(2025-03-28)[2025-08-02].https://www.biorxiv.org/content/10.1101/2021.06.08.447649.点此复制
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