有氧运动和饮食控制对肥胖小鼠体内Visfatin水平的影响及其与氧化应激的关系

Objective：To study the differences of oxidative stress (OS) on obesity mice separately intervened by aerobic exercise and diet control, and the relationship with visfatin levels of visceral adipose tissue (VAT) and serum. Methods：Fifty C57BL/6J male mice were used as the research object, high-fat diet was used to establish obesity model, aerobic exercise and diet control were regarded as intervention. After eight weeks, levels of triglyceride (TG), total cholesterol (CHO), T-SOD, GSH-px, MDA and visfatin levels in serum were detected by ELISA; visfatin mRNA levels in VAT were determined by RT-PCR. Results: (1) Visfatin levels in obesity model were higher than the normal diet group. (2) Diet control can down-regulate the levels of visfatin mRNA in VAT; visfatin levels in serum lower but visfatin mRNA in VAT were higher than the obesity group after exercise intervention.(3) Aerobic exercise and diet control can improve antioxidant capacity; aerobic exercise can down-regulate the levels of oxidative stress.(4) Oxidative stress was positively related to visfatin levels. Conclusion: Aerobic exercise and diet control can down-regulate the levels of OS and visfatin in obese mice and improve their antioxidant capacity.