Theta activity paradoxically boosts gamma and ripple frequency sensitivity in prefrontal interneurons
Theta activity paradoxically boosts gamma and ripple frequency sensitivity in prefrontal interneurons
Abstract Fast oscillations in cortical circuits critically depend on GABAergic interneurons. Which interneuron types and populations can drive different cortical rhythms, however, remains unresolved and may depend on brain state. Here, we measured the sensitivity of different GABAergic interneurons in prefrontal cortex under conditions mimicking distinct brain states. While fast-spiking neurons always exhibited a wide bandwidth of around 400 Hz, the response properties of spike-frequency adapting interneurons switched with the background input’s statistics. Slowly fluctuating background activity, as typical for sleep or quiet wakefulness, dramatically boosted the neurons’ sensitivity to gamma- and ripple-frequencies. A novel time-resolved dynamic gain analysis revealed rapid sensitivity modulations that enable neurons to periodically boost gamma oscillations and ripples during specific phases of ongoing low-frequency oscillations. This mechanism presumably contributes substantially to cross-frequency coupling and predicts these prefrontal interneurons to be exquisitely sensitive to high-frequency ripples, especially during brain states characterized by slow rhythms.
Staiger Jochen F.、Neef Andreas、Wolf Fred、St¨1hmer Walter、Merino Ricardo Martins、Leon-Pinzon Carolina、M?ck Martin
Institute for Neuroanatomy, University Medical Center G?ttingen, Georg-August-UniversityMax Planck Institute for Dynamics and Self-Organization||G?ttingen Campus Institute for Dynamics of Biological Networks||Bernstein Center for Computational Neuroscience G?ttingen||Max Planck Institute of Experimental Medicine||Institute for Nonlinear Dynamics, Georg-August University School of Science||Center for Biostructural Imaging of NeurodegenerationMax Planck Institute for Dynamics and Self-Organization||G?ttingen Campus Institute for Dynamics of Biological Networks||Bernstein Center for Computational Neuroscience G?ttingen||Max Planck Institute of Experimental Medicine||Institute for Nonlinear Dynamics, Georg-August University School of Science||Center for Biostructural Imaging of NeurodegenerationBernstein Center for Computational Neuroscience G?ttingen||Max Planck Institute of Experimental MedicineMax Planck Institute for Dynamics and Self-Organization||G?ttingen Campus Institute for Dynamics of Biological Networks||Bernstein Center for Computational Neuroscience G?ttingen||G?ttingen Graduate Center for Neurosciences, Biophysics, and Molecular Biosciences, University of G?ttingen||Max Planck Institute of Experimental MedicineMax Planck Institute for Dynamics and Self-Organization||G?ttingen Campus Institute for Dynamics of Biological Networks||Bernstein Center for Computational Neuroscience G?ttingen||Max Planck Institute of Experimental MedicineInstitute for Neuroanatomy, University Medical Center G?ttingen, Georg-August-University
生物物理学生理学细胞生物学
Staiger Jochen F.,Neef Andreas,Wolf Fred,St¨1hmer Walter,Merino Ricardo Martins,Leon-Pinzon Carolina,M?ck Martin.Theta activity paradoxically boosts gamma and ripple frequency sensitivity in prefrontal interneurons[EB/OL].(2025-03-28)[2025-05-03].https://www.biorxiv.org/content/10.1101/2019.12.19.882639.点此复制
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