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Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans

Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans

来源:bioRxiv_logobioRxiv
英文摘要

Life experiences trigger transgenerational small RNA-based responses in C. elegans nematodes. Dedicated machinery ensures that heritable effects would re-set, typically after a few generations. Here we show that isogenic individuals differ dramatically in the persistence of transgenerational responses. By examining lineages composed of >20,000 worms we reveal 3 inheritance rules: (1) Once a response is initiated, each isogenic mother stochastically assumes an “inheritance state”, establishing a commitment that determines the fate of the inheritance. (2) The response that each mother transfers is uniform in each generation of her descendants. (3) The likelihood that an RNAi response would transmit to the progeny increases the more generations the response lasts, according to a “hot hand” principle. Mechanistically, the different parental “inheritance states” correspond to global changes in the expression levels of endogenous small RNAs, immune response genes, and targets of the conserved transcription factor HSF-1. We show that these rules predict the descendants’ developmental rate and resistance to stress.

Houri-Ze?ˉevi Leah、Rechavi Oded、Antonova Olga

Department of Neurobiology, Wise Faculty of Life Sciences & Sagol School of Neuroscience, Tel Aviv UniversityDepartment of Neurobiology, Wise Faculty of Life Sciences & Sagol School of Neuroscience, Tel Aviv UniversityDepartment of Neurobiology, Wise Faculty of Life Sciences & Sagol School of Neuroscience, Tel Aviv University

10.1101/2020.01.08.899203

遗传学分子生物学

Houri-Ze?ˉevi Leah,Rechavi Oded,Antonova Olga.Three Rules Explain Transgenerational Small RNA Inheritance in C. elegans[EB/OL].(2025-03-28)[2025-05-09].https://www.biorxiv.org/content/10.1101/2020.01.08.899203.点此复制

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