Demyelination induces selective vulnerability of inhibitory networks in multiple sclerosis
Demyelination induces selective vulnerability of inhibitory networks in multiple sclerosis
In multiple sclerosis (MS), a chronic demyelinating disease of the central nervous system, neurodegeneration is detected early in the disease course and is associated with the long-term disability of patients. Neurodegeneration is linked to both inflammation and demyelination, but its exact cause remains unknown. This gap in knowledge contributes to the current lack of treatments for the neurodegenerative phase of MS. Here we ask if neurodegeneration in MS affects specific neuronal components and if it is the result of demyelination. Neuropathological examination of secondary progressive MS motor cortices revealed a selective vulnerability of inhibitory interneurons in MS. The generation of a rodent model of focal subpial cortical demyelination proved that this selective neurodegeneration is secondary to demyelination providing the first temporal evidence of demyelination-induced neurodegeneration and a new preclinical model for the study of neuroprotective treatments.
Werner Carsten、Spires-Jones Tara L.、Williams Anna C.、Newland Ben、Zoupi Lida、Booker Sam A.、Kind Peter C.、Eigel Dimitri
Leibniz-Institut f¨1r Polymerforschung Dresden e.V., Max Bergmann Center of Biomaterials DresdenCentre for Discovery Brain Sciences, University of Edinburgh||UK Dementia Research Institute, University of EdinburghCentre for Regenerative Medicine, Institute for Regeneration and Repair, University of EdinburghLeibniz-Institut f¨1r Polymerforschung Dresden e.V., Max Bergmann Center of Biomaterials Dresden||School of Pharmacy and Pharmaceutical Sciences, Cardiff UniversityCentre for Regenerative Medicine, Institute for Regeneration and Repair, University of EdinburghCentre for Discovery Brain Sciences, University of Edinburgh||Simons Initiative for the Developing Brain, University of Edinburgh||Patrick Wild Centre for Autism Research, University of EdinburghCentre for Discovery Brain Sciences, University of Edinburgh||Simons Initiative for the Developing Brain, University of Edinburgh||Patrick Wild Centre for Autism Research, University of EdinburghLeibniz-Institut f¨1r Polymerforschung Dresden e.V., Max Bergmann Center of Biomaterials Dresden
神经病学、精神病学基础医学医学研究方法
Werner Carsten,Spires-Jones Tara L.,Williams Anna C.,Newland Ben,Zoupi Lida,Booker Sam A.,Kind Peter C.,Eigel Dimitri.Demyelination induces selective vulnerability of inhibitory networks in multiple sclerosis[EB/OL].(2025-03-28)[2025-08-02].https://www.biorxiv.org/content/10.1101/2020.09.17.302042.点此复制
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