Pharmacokinetics of remdesivir in a COVID-19 patient with end-stage renal disease on intermittent hemodialysis
Pharmacokinetics of remdesivir in a COVID-19 patient with end-stage renal disease on intermittent hemodialysis
Abstract Remdesivir, a drug with provisional approval for the treatment of COVID-19, is not recommended in patients with an estimated glomerular filtration rate ≤ 30 mL/min. Here we provide a first detailed pharmacokinetic assessment of remdesivir and its major metabolites in a patient with end stage renal disease on hemodialysis.
S?rgel Fritz、Malin Jakob J.、Hagmann Henning、Kinzig Martina、Eichenauer Dennis A.、Scherf-Clavel Oliver、Rybniker Jan、Simonis Alexander、Bilal Muhammad、Tabei Lobna El、Fuhr Uwe
IBMP ¨C Institute for Biomedical and Pharmaceutical Research||Institute of Pharmacology, West German Heart and Vascular Centre, University of Duisburg-EssenDepartment I of Internal Medicine, Division of Infectious Diseases, University of Cologne||Faculty of Medicine, Center for Molecular Medicine Cologne (CMMC), University of Cologne||German Center for Infection Research (DZIF), Partner Site Bonn-CologneFaculty of Medicine, Center for Molecular Medicine Cologne (CMMC), University of Cologne||Department II of Internal Medicine, University Hospital CologneIBMP ¨C Institute for Biomedical and Pharmaceutical ResearchUniversity of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne DusseldorfIBMP ¨C Institute for Biomedical and Pharmaceutical Research||University of Wuerzburg, Institute for Pharmacy and Food ChemistryDepartment I of Internal Medicine, Division of Infectious Diseases, University of Cologne||Faculty of Medicine, Center for Molecular Medicine Cologne (CMMC), University of Cologne||German Center for Infection Research (DZIF), Partner Site Bonn-CologneDepartment I of Internal Medicine, Division of Infectious Diseases, University of Cologne||Faculty of Medicine, Center for Molecular Medicine Cologne (CMMC), University of CologneFaculty of Medicine and University Hospital Cologne, Center for Pharmacology, Department I of Pharmacology, University of CologneFaculty of Medicine and University Hospital Cologne, Center for Pharmacology, Department I of Pharmacology, University of CologneFaculty of Medicine and University Hospital Cologne, Center for Pharmacology, Department I of Pharmacology, University of Cologne
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S?rgel Fritz,Malin Jakob J.,Hagmann Henning,Kinzig Martina,Eichenauer Dennis A.,Scherf-Clavel Oliver,Rybniker Jan,Simonis Alexander,Bilal Muhammad,Tabei Lobna El,Fuhr Uwe.Pharmacokinetics of remdesivir in a COVID-19 patient with end-stage renal disease on intermittent hemodialysis[EB/OL].(2025-03-28)[2025-08-02].https://www.medrxiv.org/content/10.1101/2020.10.28.20216887.点此复制
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