Pan-embryo cell dynamics of germlayer formation in zebrafish
Pan-embryo cell dynamics of germlayer formation in zebrafish
Abstract Cell movements are coordinated across spatio-temporal scales to achieve precise positioning of organs during vertebrate gastrulation. In zebrafish, mechanisms governing such morphogenetic movements have so far only been studied within a local region or a single germlayer. Here, we present pan-embryo analyses of fate specification and dynamics of all three germlayers simultaneously within a gastrulating embryo, showing that cell movement characteristics are predominantly determined by its position within the embryo, independent of its germlayer identity. The spatially confined fate specification establishes a distinct distribution of cells in each germlayer during early gastrulation. The differences in the initial distribution are subsequently amplified by a unique global movement, which organizes the organ precursors along the embryonic body axis, giving rise to the blueprint of organ formation.
Schmid Benjamin、Roeder Ingo、Shah Gopi、Reade Anna、Thierbach Konstantin、Scherf Nico、Huisken Jan
Max Planck Institute of Molecular Cell Biology and Genetics||Optical Imaging Centre Erlangen, Friedrich-Alexander-University of Erlangen-NurembergInstitute for Medical Informatics and Biometry, Medical SchoolMax Planck Institute of Molecular Cell Biology and Genetics||Cancer Research UK Cambridge Institute, University of CambridgeCardiovascular Research Institute, University of California||Department of Biochemistry and Biophysics, University of CaliforniaInstitute for Medical Informatics and Biometry, Medical SchoolMax Planck Institute of Molecular Cell Biology and Genetics||Institute for Medical Informatics and Biometry, Medical SchoolMax Planck Institute of Molecular Cell Biology and Genetics||Morgridge Institute for Research
细胞生物学分子生物学普通生物学
Schmid Benjamin,Roeder Ingo,Shah Gopi,Reade Anna,Thierbach Konstantin,Scherf Nico,Huisken Jan.Pan-embryo cell dynamics of germlayer formation in zebrafish[EB/OL].(2025-03-28)[2025-04-26].https://www.biorxiv.org/content/10.1101/173583.点此复制
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