α-Synuclein facilitates dopamine release during burst firing of substantia nigra neurons in vivo
α-Synuclein facilitates dopamine release during burst firing of substantia nigra neurons in vivo
Abstract α-Synuclein is expressed at high levels at presynaptic terminals, but defining its role on neurotransmission under physiologically-relevant conditions has proven elusive. We report that α-synuclein is responsible for a rapid facilitation of dopamine release during action potential bursts in vivo. This occurs in tandem with a far slower stimulus-dependent depression, appears to be independent of the presence of β- and γ-synucleins or effects on presynaptic calcium and is consistent with a role for synucleins in the enhancement of synaptic vesicle fusion and turnover. The results indicate that the presynaptic effects of α-synuclein are dependent on specific patterns of neuronal activity.
Somayaji Mahalakshmi、Cataldi Stefano、Mosharov Eugene V.、Edwards Robert H.、Sulzer David
Departments of Psychiatry, Neurology, Pharmacology, Columbia University. and Division of Molecular Therapeutics, New York State Psychiatric InstituteDepartments of Psychiatry, Neurology, Pharmacology, Columbia University. and Division of Molecular Therapeutics, New York State Psychiatric InstituteDepartments of Psychiatry, Neurology, Pharmacology, Columbia University. and Division of Molecular Therapeutics, New York State Psychiatric InstituteDepartments of Neurology, Physiology, UCSFDepartments of Psychiatry, Neurology, Pharmacology, Columbia University. and Division of Molecular Therapeutics, New York State Psychiatric Institute
神经病学、精神病学基础医学生理学
Somayaji Mahalakshmi,Cataldi Stefano,Mosharov Eugene V.,Edwards Robert H.,Sulzer David.α-Synuclein facilitates dopamine release during burst firing of substantia nigra neurons in vivo[EB/OL].(2025-03-28)[2025-08-26].https://www.biorxiv.org/content/10.1101/2020.06.10.145110.点此复制
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