Monitoring transmission intensity of trachoma with serology: a multi-country study
Monitoring transmission intensity of trachoma with serology: a multi-country study
Abstract Trachoma, caused by ocular Chlamydia trachomatis infection, is targeted for global elimination as a public health problem by 2030. To provide evidence for use of antibodies to monitor C. trachomatis transmission, we collated IgG responses to Pgp3 antigen, PCR positivity, and clinical observations from 19,811 children aged 1–9 years in 14 populations. We demonstrate that age-seroprevalence curves consistently shift along a gradient of transmission intensity: rising steeply in populations with high levels of infection and active trachoma and becoming flat in populations near elimination. Seroprevalence (range: 0–54%) and seroconversion rates (range: 0–15 per 100 person-years) correlate with PCR prevalence (r: 0.88, 95% CI: 0.77, 0.93). A seroprevalence threshold of 13.5% (seroconversion rate 2.75 per 100 person-years) identifies clusters with any infection at high sensitivity (>90%) and moderate specificity (69-75%). Antibody responses in young children provide a robust, generalizable approach to monitor population progress toward and beyond trachoma elimination.
Kadri Boubacar、Solomon Anthony W.、Nash Scott D.、Lammie Patrick J.、Aragie Solomon、Tadesse Zerihun、Wittberg Dionna M.、Callahan E. Kelly、Carolan Sydney、Gwyn Sarah、Hammou Jaouad、Kalua Khumbo、Nassirou Beido、Zeru Taye、Seife Fikre、Lietman Thomas M.、Amza Abdou、Keenan Jeremy D.、Tedijanto Christine、Martin Diana L.、Arzika Ahmed M.、Dawed Adisu Abebe、Arnold Benjamin F.、West Sheila K.、Aiemjoy Kristen、Goodhew E. Brook、Maliki Ramatou
Programme National de Lutte Contre la Cecit¨|Department of Control of Neglected Tropical DiseasesThe Carter CenterNeglected Tropical Diseases Support Center, Task Force for Global HealthThe Carter Center EthiopiaThe Carter Center EthiopiaFrancis I. Proctor Foundation, University of California San FranciscoThe Carter CenterFrancis I. Proctor Foundation, University of California San FranciscoDivision of Parasitic Diseases and Malaria, Centers for Disease Control and PreventionService of Ocular and Otological Diseases, Epidemiology and Disease Control Directorate, Ministry of HealthBlantyre Institute for Community OutreachProgramme National de Lutte Contre la Cecit¨|Amhara Public Health InstituteFederal Ministry of Health, Addis AbabaFrancis I. Proctor Foundation, University of California San Francisco||Department of Ophthalmology, University of California San Francisco||Institute for Global Health Sciences, University of California San Francisco||Department of Epidemiology and Biostatistics, University of California San FranciscoProgramme FSS/Universit¨| Abdou Moumouni de Niamey, Programme National de Sant¨| Oculaire||Programme National de Lutte Contre la Cecit¨|Francis I. Proctor Foundation, University of California San Francisco||Department of Ophthalmology, University of California San FranciscoFrancis I. Proctor Foundation, University of California San FranciscoDivision of Parasitic Diseases and Malaria, Centers for Disease Control and PreventionThe Carter Center NigerAmhara Regional Health BureauFrancis I. Proctor Foundation, University of California San Francisco||Department of Ophthalmology, University of California San FranciscoJohns Hopkins School of Medicine, Ophthalmology DepartmentDivision of Epidemiology, Department of Public Health Sciences, University of California Davis School of MedicineDivision of Parasitic Diseases and Malaria, Centers for Disease Control and PreventionThe Carter Center Niger
眼科学医学研究方法预防医学
Kadri Boubacar,Solomon Anthony W.,Nash Scott D.,Lammie Patrick J.,Aragie Solomon,Tadesse Zerihun,Wittberg Dionna M.,Callahan E. Kelly,Carolan Sydney,Gwyn Sarah,Hammou Jaouad,Kalua Khumbo,Nassirou Beido,Zeru Taye,Seife Fikre,Lietman Thomas M.,Amza Abdou,Keenan Jeremy D.,Tedijanto Christine,Martin Diana L.,Arzika Ahmed M.,Dawed Adisu Abebe,Arnold Benjamin F.,West Sheila K.,Aiemjoy Kristen,Goodhew E. Brook,Maliki Ramatou.Monitoring transmission intensity of trachoma with serology: a multi-country study[EB/OL].(2025-03-28)[2025-08-02].https://www.medrxiv.org/content/10.1101/2023.02.13.23285881.点此复制
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