A brainstem-central amygdala circuit underlies defensive responses to learned threats
A brainstem-central amygdala circuit underlies defensive responses to learned threats
Abstract Norepinephrine (NE) plays a central role in the acquisition of aversive learning via actions in the lateral nucleus of the amygdala (LA)1,2. However, the function of NE in expression of aversively-conditioned responses has not been established. Given the role of the central nucleus of the amygdala (CeA) in the expression of such behaviors3, and the presence of NE projections in this brain nucleus, we assessed the effects of NE activity in the CeA on behavioral expression using receptor-specific pharmacology and cell- and projection-specific chemogenetic manipulations. We found that inhibition and activation of locus coeruleus (LC) neurons decreases and increases freezing to aversively conditioned cues, respectively. We then show that locally inhibiting or activating LC terminals in CeA is sufficient to achieve this bidirectional modulation of defensive reactions. These findings support the hypothesis that LC projections to CeA are required for the expression of defensive responses elicited by conditioned threats.
LeDoux Joseph E.、Vazey Elena M.、Aston-Jones Gary、Lin Longnian、Sears Robert M、Gu Yiran
Key Laboratory of Brain Functional Genomics (Ministry of Education and Shanghai), School of Life Science and the Collaborative Innovation Center for Brain Science, Institute of Brain Functional Genomics, East China Normal University||Center for Neural Science, New York University||Emotional Brain Institute, The Nathan Kline InstituteDepartment of Biology, University of MassachusettsBrain Health Institute, Rutgers University/Rutgers Biomedical and Health SciencesKey Laboratory of Brain Functional Genomics (Ministry of Education and Shanghai), School of Life Science and the Collaborative Innovation Center for Brain Science, Institute of Brain Functional Genomics, East China Normal UniversityCenter for Neural Science, New York University||Emotional Brain Institute, The Nathan Kline Institute||Department of Child and Adolescent Psychiatry, New York University Langone School of MedicineKey Laboratory of Brain Functional Genomics (Ministry of Education and Shanghai), School of Life Science and the Collaborative Innovation Center for Brain Science, Institute of Brain Functional Genomics, East China Normal University||Center for Neural Science, New York University||Department of Psychiatry, McLean Hospital, Harvard Medical School
基础医学神经病学、精神病学生理学
LeDoux Joseph E.,Vazey Elena M.,Aston-Jones Gary,Lin Longnian,Sears Robert M,Gu Yiran.A brainstem-central amygdala circuit underlies defensive responses to learned threats[EB/OL].(2025-03-28)[2025-04-25].https://www.biorxiv.org/content/10.1101/519249.点此复制
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