Adhesion to nanofibers drives cell membrane remodeling through 1D wetting
Adhesion to nanofibers drives cell membrane remodeling through 1D wetting
Abstract The shape of cellular membranes is highly regulated by a set of conserved mechanisms. These mechanisms can be manipulated by bacterial pathogens to infect cells. Human endothelial cell plasma membrane remodeling by the bacterium Neisseria meningitidis is thought to be essential during the blood phase of meningococcal infection, but the underlying mechanisms are unknown. Here we show that plasma membrane remodeling occurs independently of F-actin, along meningococcal type IV pili fibers, by a novel physical mechanism we term “ onedimensional” membrane wetting. We provide a theoretical model that gives the physical basis of 1D wetting and show that this mechanism occurs in model membranes interacting with model nanofibers, and in human cells interacting with model extracellular matrices. It is thus a new general principle driving the interaction of cells with their environment at the nanoscale that is diverted by meningococcus during infection.
Bonazzi Daria、Sachse Martin、Melican Keira、Staneva Ralitza、Bertin Aur¨|lie、Goussard Sylvie、Lafaye Pierre、Shorte Spencer、Bassereau Patricia、Dum¨|nil Guillaume、Millien Corinne、Mallet Adeline、Manriquez Valeria、Tsai Feng-Ching、Brochard-Wyart Fran?oise、Piel Matthieu、Krijnse-Locker Jacomine、Charles-Orszag Arthur、Salles Audrey
Pathogenesis of Vascular Infections Unit, INSERM, Institut PasteurUltrapole, Institut PasteurPathogenesis of Vascular Infections Unit, INSERM, Institut PasteurInstitut Curie, PSL Research UniversityLaboratoire Physico Chimie Curie, Institut Curie, PSL Research University||Sorbonne Universit¨|Pathogenesis of Vascular Infections Unit, INSERM, Institut PasteurAntibody Engineering, Institut PasteurImagopole, Institut PasteurLaboratoire Physico Chimie Curie, Institut Curie, PSL Research University||Sorbonne Universit¨|Pathogenesis of Vascular Infections Unit, INSERM, Institut PasteurParis Cardiovascular Research CenterUltrapole, Institut PasteurPathogenesis of Vascular Infections Unit, INSERM, Institut Pasteur||Universit¨| Paris Descartes, Sorbonne Paris Cit¨|Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University||Sorbonne Universit¨|Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University||Sorbonne Universit¨|Systems Biology of Cell Polarity and Cell Division, Institut Pierre-Gilles De Gennes||Institut CurieUltrapole, Institut PasteurPathogenesis of Vascular Infections Unit, INSERM, Institut Pasteur||Universit¨| Paris Descartes, Sorbonne Paris Cit¨|Imagopole, Institut Pasteur
细胞生物学分子生物学基础医学
Bonazzi Daria,Sachse Martin,Melican Keira,Staneva Ralitza,Bertin Aur¨|lie,Goussard Sylvie,Lafaye Pierre,Shorte Spencer,Bassereau Patricia,Dum¨|nil Guillaume,Millien Corinne,Mallet Adeline,Manriquez Valeria,Tsai Feng-Ching,Brochard-Wyart Fran?oise,Piel Matthieu,Krijnse-Locker Jacomine,Charles-Orszag Arthur,Salles Audrey.Adhesion to nanofibers drives cell membrane remodeling through 1D wetting[EB/OL].(2025-03-28)[2025-04-28].https://www.biorxiv.org/content/10.1101/393744.点此复制
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