Saliva swabs are the preferred sample for Omicron detection
Saliva swabs are the preferred sample for Omicron detection
Abstract The Omicron variant is characterised by more than 50 distinct mutations, the majority of which are located in the spike protein. The implications of these mutations for disease transmission, tissue tropism and diagnostic testing are still to be determined. We evaluated the relative performance of saliva and mid-turbinate swabs as RT-PCR samples for the Delta and Omicron variants. The positive percent agreement (PPA) of saliva swabs and mid-turbinate swabs to a composite standard was 71% (95% CI: 53-84%) and 100% (95% CI: 89-100%), respectively, for the Delta variant. However, for the Omicron variant saliva and mid-turbinate swabs had a 100% (95% CI: 90-100%) and 86% (95% CI: 71-94%) PPA, respectively. This finding supports ex-vivo data of altered tissue tropism from other labs for the Omicron variant. Reassessment of the diagnostic testing standard-of-care may be required as the Omicron variant become the dominant variant worldwide.
Hsiao Nei-yuan、Marais Gert、Enoch Annabel、Chu Chun-yat、Brink Adrian、Hardie Diana、Iranzadeh Arash、Doolabh Deelan、Williamson Carolyn
Department of Medical Virology, University of Cape TownDepartment of Medical Microbiology, University of Cape TownGreen Point Diagnostic Virology Laboratory, National Health Laboratory ServiceDepartment of Medical Microbiology, University of Cape TownDepartment of Medical Microbiology, University of Cape TownDepartment of Medical Virology, University of Cape TownDepartment of Medical Virology, University of Cape TownDepartment of Medical Virology, University of Cape TownDepartment of Medical Virology, University of Cape Town
医学研究方法医学现状、医学发展基础医学
Hsiao Nei-yuan,Marais Gert,Enoch Annabel,Chu Chun-yat,Brink Adrian,Hardie Diana,Iranzadeh Arash,Doolabh Deelan,Williamson Carolyn.Saliva swabs are the preferred sample for Omicron detection[EB/OL].(2025-03-28)[2025-05-28].https://www.medrxiv.org/content/10.1101/2021.12.22.21268246.点此复制
评论