Visual cue-related activity of cells in the medial entorhinal cortex during navigation in virtual reality
Visual cue-related activity of cells in the medial entorhinal cortex during navigation in virtual reality
Abstract During spatial navigation, animals use self-motion to estimate positions through path integration. However, estimation errors accumulate over time and it is unclear how they are corrected. Here we report a new cell class (“cue cell”) in mouse medial entorhinal cortex (MEC) that encoded visual cue information that could be used to correct errors in path integration. Cue cells accounted for a large fraction of unidentified MEC cells. They exhibited firing fields only near visual cues during virtual navigation and spatially stable activity during navigation in a real arena. Cue cells’ responses occurred in sequences repeated at each cue and were likely driven by visual inputs. In layers 2/3 of the MEC, cue cells formed clusters. Anatomically adjacent cue cells responded similarly to cues. These cue cell properties demonstrate that the MEC circuits contain a code representing spatial landmarks that could play a significant role in error correction during path integration.
Kinkhabwala Amina A.、Aronov Dmitriy、Tank David W.、Gu Yi
Princeton Neuroscience Institute, Princeton University||Bezos Center for Neural Circuit Dynamics, Princeton University||Department of Molecular Biology, Princeton UniversityPrinceton Neuroscience Institute, Princeton University||Bezos Center for Neural Circuit Dynamics, Princeton University||Department of Molecular Biology, Princeton UniversityPrinceton Neuroscience Institute, Princeton University||Bezos Center for Neural Circuit Dynamics, Princeton University||Department of Molecular Biology, Princeton UniversityPrinceton Neuroscience Institute, Princeton University||Bezos Center for Neural Circuit Dynamics, Princeton University||Department of Molecular Biology, Princeton University
细胞生物学生物物理学生理学
Kinkhabwala Amina A.,Aronov Dmitriy,Tank David W.,Gu Yi.Visual cue-related activity of cells in the medial entorhinal cortex during navigation in virtual reality[EB/OL].(2025-03-28)[2025-04-27].https://www.biorxiv.org/content/10.1101/453787.点此复制
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