History of childbirths relates to region-specific brain aging patterns in middle and older-aged women
History of childbirths relates to region-specific brain aging patterns in middle and older-aged women
Abstract Pregnancy involves maternal brain adaptations, but little is known about how parity influences women’s brain aging trajectories later in life. In this study, we replicated previous findings showing less apparent brain aging in women with a history of childbirths, and identified regional brain aging patterns linked to parity in 19,787 middle and older-aged women. Using novel applications of brain-age prediction methods, we found that a higher number of previous childbirths was linked to less apparent brain aging in striatal and limbic regions. The strongest effect was found in the accumbens – a key region in the mesolimbic reward system, which plays an important role in maternal behavior. While only prospective longitudinal studies would be conclusive, our findings indicate that subcortical brain modulations during pregnancy and postpartum may be traceable decades after childbirth.
Kaufmann Tobias、Ebmeier Klaus P.、Westlye Lars T.、de Lange Ann-Marie G.、Suri Sana、Barth Claudia、Anat¨1rk Melis
NORMENT, Institute of Clinical Medicine, University of Oslo, & Division of Mental Health and Addiction, Oslo University HospitalDepartment of Psychiatry, University of OxfordDepartment of Psychology, University of Oslo||NORMENT, Institute of Clinical Medicine, University of Oslo, & Division of Mental Health and Addiction, Oslo University Hospital||KG Jebsen Centre for Neurodevelopmental Disorders, University of OsloDepartment of Psychiatry, University of Oxford||Department of Psychology, University of Oslo||NORMENT, Institute of Clinical Medicine, University of Oslo, & Division of Mental Health and Addiction, Oslo University HospitalDepartment of Psychiatry, University of Oxford||Wellcome Centre for Integrative Neuroimaging, University of OxfordNORMENT, Institute of Clinical Medicine, University of Oslo, & Division of Mental Health and Addiction, Oslo University HospitalDepartment of Psychiatry, University of Oxford||Wellcome Centre for Integrative Neuroimaging, University of Oxford
妇产科学神经病学、精神病学基础医学
Kaufmann Tobias,Ebmeier Klaus P.,Westlye Lars T.,de Lange Ann-Marie G.,Suri Sana,Barth Claudia,Anat¨1rk Melis.History of childbirths relates to region-specific brain aging patterns in middle and older-aged women[EB/OL].(2025-03-28)[2025-05-03].https://www.biorxiv.org/content/10.1101/2020.05.08.084616.点此复制
评论