Epigenetic Divergence during Early Stages of Speciation in an African Crater Lake Cichlid Fish
Epigenetic Divergence during Early Stages of Speciation in an African Crater Lake Cichlid Fish
Abstract Epigenetic variation can alter transcription and promote phenotypic divergence between populations facing different environmental challenges. Here we assess the epigenetic basis of diversification during the early stages of speciation. We focus on the extent and functional relevance of DNA methylome divergence between two Astatotilapia calliptera ecomorphs in crater Lake Masoko, southern Tanzania. We report extensive genome-wide methylome divergence between populations linked to key biological processes, including transcriptional activity of ecologically-relevant genes. These include genes involved in steroid metabolism, haemoglobin composition and erythropoiesis, consistent with divergent habitat occupancy of the ecomorphs. Using a common garden experiment, we found that global methylation profiles are rapidly remodelled across generations, but ecomorph-specific differences can be inherited. Collectively, our study suggests an epigenetic contribution to early stages of vertebrate speciation. One sentence summaryInheritance and plasticity of epigenetic divergence characterise early stages of speciation in an incipient cichlid species of an African crater lake.
Vernaz Gr¨|goire、Fischer Bettina、Carruthers Madeleine、Shechonge Asilatu H.、Durbin Richard、Turner George F.、Genner Martin J.、Miska Eric A.、Malinsky Milan、Ngatunga Benjamin P.、Hudson Alan G.、Gabagambi Nestory P.、Tyers Alexandra M.、Em¨alia Santos M.
Wellcome/CRUK Gurdon Institute, University of Cambridge||Department of Genetics, University of Cambridge||Wellcome Sanger InstituteDepartment of Genetics, University of CambridgeSchool of Biological Sciences, University of BristolTanzania Fisheries Research Institute (TAFIRI)Department of Genetics, University of Cambridge||Wellcome Sanger InstituteSchool of Natural Sciences, Bangor UniversitySchool of Biological Sciences, University of BristolWellcome/CRUK Gurdon Institute, University of Cambridge||Department of Genetics, University of Cambridge||Wellcome Sanger InstituteWellcome Sanger Institute||Institute of Ecology and Evolution, University of BernTanzania Fisheries Research Institute (TAFIRI)School of Biological Sciences, University of Bristol||School of Life Sciences, University of Hawai?ˉi at M¨?noaTanzania Fisheries Research Institute (TAFIRI)School of Natural Sciences, Bangor University||Max Planck Institute for Biology of AgeingDepartment of Zoology, University of Cambridge
遗传学分子生物学动物学
Vernaz Gr¨|goire,Fischer Bettina,Carruthers Madeleine,Shechonge Asilatu H.,Durbin Richard,Turner George F.,Genner Martin J.,Miska Eric A.,Malinsky Milan,Ngatunga Benjamin P.,Hudson Alan G.,Gabagambi Nestory P.,Tyers Alexandra M.,Em¨alia Santos M..Epigenetic Divergence during Early Stages of Speciation in an African Crater Lake Cichlid Fish[EB/OL].(2025-03-28)[2025-04-26].https://www.biorxiv.org/content/10.1101/2021.07.30.435319.点此复制
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