Perceptual detection depends on spike count integration
Perceptual detection depends on spike count integration
Abstract Whenever the retinal image changes some neurons in visual cortex increase their rate of firing, while others decrease their rate of firing. Linking specific sets of neuronal responses with perception and behavior is essential for understanding mechanisms of neural circuit computation. We trained mice to perform visual detection tasks and used optogenetic perturbations to increase or decrease neuronal spiking primary visual cortex (V1). Perceptual reports were always enhanced by increments in V1 spike counts and impaired by decrements, even when increments and decrements were delivered to the same neuronal populations. Moreover, detecting changes in cortical activity depended on spike count integration rather than instantaneous changes in spiking. Recurrent neural networks trained in the task similarly relied on increments in neuronal activity when activity was costly. This work clarifies neuronal decoding strategies employed by cerebral cortex to translate cortical spiking into percepts that can be used to guide behavior.
Bade Morgan L.、Page Elizabeth A.、Cone Jackson J.、Freedman David J.、Masse Nicolas Y.、Maunsell John H.R.
Department of Neurobiology and Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, University of ChicagoDepartment of Neurobiology and Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, University of ChicagoDepartment of Neurobiology and Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, University of ChicagoDepartment of Neurobiology and Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, University of ChicagoDepartment of Neurobiology and Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, University of ChicagoDepartment of Neurobiology and Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior, University of Chicago
生物科学理论、生物科学方法生物科学研究方法、生物科学研究技术生理学生物物理学
Bade Morgan L.,Page Elizabeth A.,Cone Jackson J.,Freedman David J.,Masse Nicolas Y.,Maunsell John H.R..Perceptual detection depends on spike count integration[EB/OL].(2025-03-28)[2025-05-09].https://www.biorxiv.org/content/10.1101/865410.点此复制
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