A SOSEKI-based coordinate system interprets global polarity cues in Arabidopsis
A SOSEKI-based coordinate system interprets global polarity cues in Arabidopsis
Multicellular development requires coordinated cell polarization relative to body axes, and translation to oriented cell division. In plants, it is unknown how cell polarities are connected to organismal axes and translated to division. Here, we identify Arabidopsis SOSEKI (SOK) proteins that integrate apical-basal and radial organismal axes to localize to polar cell edges. Localization does not depend on tissue context, requires cell wall integrity and is defined by a transferrable, protein-specific motif. SOK proteins structurally resemble the DIX oligomerization domain in the animal Dishevelled polarity regulator. The DIX-like domain self-interacts and is required for edge localization and for influencing division orientation. Our work identifies a plant compass, interpreted by SOK proteins. Furthermore, despite fundamental differences, polarity in plants and animals converge upon the same protein domain.
Adibi Milad、Marhavy Peter、Friml Jiri、Weijers Dolf、Schuren Alja van der、M?ller Barbara、van Galen Luc、van Dop Maritza、Saiga Shunsuke、Yoshida Saiko、Smith Richard
Department of Comparative Development and Genetics, Max Planck Institute for Plant Breeding ResearchInstitute of Science and TechnologyInstitute of Science and TechnologyLaboratory of Biochemistry, Wageningen UniversityLaboratory of Biochemistry, Wageningen UniversityLaboratory of Biochemistry, Wageningen UniversityLaboratory of Biochemistry, Wageningen UniversityLaboratory of Biochemistry, Wageningen UniversityLaboratory of Biochemistry, Wageningen UniversityLaboratory of Biochemistry, Wageningen University||Institute of Science and TechnologyDepartment of Comparative Development and Genetics, Max Planck Institute for Plant Breeding Research
细胞生物学植物学分子生物学
Adibi Milad,Marhavy Peter,Friml Jiri,Weijers Dolf,Schuren Alja van der,M?ller Barbara,van Galen Luc,van Dop Maritza,Saiga Shunsuke,Yoshida Saiko,Smith Richard.A SOSEKI-based coordinate system interprets global polarity cues in Arabidopsis[EB/OL].(2025-03-28)[2025-05-22].https://www.biorxiv.org/content/10.1101/479113.点此复制
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