A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection
A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection
ABSTRACT Flexible behaviors over long timescales are thought to engage recurrent neural networks in deep brain regions, which are experimentally challenging to study. In insects, recurrent circuit dynamics in a brain region called the central complex (CX) enable directed locomotion, sleep, and context- and experience-dependent spatial navigation. We describe the first complete electron-microscopy-based connectome of the Drosophila CX, including all its neurons and circuits at synaptic resolution. We identified new CX neuron types, novel sensory and motor pathways, and network motifs that likely enable the CX to extract the fly’s head-direction, maintain it with attractor dynamics, and combine it with other sensorimotor information to perform vector-based navigational computations. We also identified numerous pathways that may facilitate the selection of CX-driven behavioral patterns by context and internal state. The CX connectome provides a comprehensive blueprint necessary for a detailed understanding of network dynamics underlying sleep, flexible navigation, and state-dependent action selection.
Noorman Marcella、Turner-Evans Daniel B.、Franconville Romain、Takemura Shinya、Dreher Marisa、Hermundstad Ann M.、Rubin Gerald M.、Jayaraman Vivek、Hulse Brad K.、Wolff Tanya、Dan Chuntao、Haberkern Hannah、Parekh Ruchi
Janelia Research Campus, Howard Hughes Medical InstituteJanelia Research Campus, Howard Hughes Medical InstituteJanelia Research Campus, Howard Hughes Medical InstituteJanelia Research Campus, Howard Hughes Medical InstituteJanelia Research Campus, Howard Hughes Medical InstituteJanelia Research Campus, Howard Hughes Medical InstituteJanelia Research Campus, Howard Hughes Medical InstituteJanelia Research Campus, Howard Hughes Medical InstituteJanelia Research Campus, Howard Hughes Medical InstituteJanelia Research Campus, Howard Hughes Medical InstituteJanelia Research Campus, Howard Hughes Medical InstituteJanelia Research Campus, Howard Hughes Medical InstituteJanelia Research Campus, Howard Hughes Medical Institute
昆虫学生物科学研究方法、生物科学研究技术生物科学现状、生物科学发展
Noorman Marcella,Turner-Evans Daniel B.,Franconville Romain,Takemura Shinya,Dreher Marisa,Hermundstad Ann M.,Rubin Gerald M.,Jayaraman Vivek,Hulse Brad K.,Wolff Tanya,Dan Chuntao,Haberkern Hannah,Parekh Ruchi.A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection[EB/OL].(2025-03-28)[2025-04-30].https://www.biorxiv.org/content/10.1101/2020.12.08.413955.点此复制
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