Phages associated with horses provide new insights into the dominance of lateral gene transfer in virulent bacteriophages evolution in natural systems
Phages associated with horses provide new insights into the dominance of lateral gene transfer in virulent bacteriophages evolution in natural systems
Abstract Tailed bacteriophages (Caudovirales order) are omnipresent on our planet. Their impressive ecological and evolutionary success largely relies on the bacteriophage potential to adapt to great variety of the environmental conditions found in the Biosphere. It is believed that the adaptation of bacteriophages, including short time scale adaptation, is achieved almost exclusively via the (micro)evolution processes. In order to analyze the major mechanisms driving adaptation of phage genomes in a natural habitat we used comparative genomics of G7C-like coliphage isolates obtained during 7 years period from the feces of the horses belonging to a local population. The data suggest that even at this relatively short time scale the impact of various recombination events overwhelms the impact of the accumulation of point mutations. The access to the large pool of the genes of a complex microbial and viral community of the animal gut had major effect on the evolutionary trajectories of these phages. Thus the “real world” bacteriophage evolution mechanisms may differ significantly from those observed in the simplified laboratory model systems.
Golomidova A.K.、Prokhorov N.S.、Maslov S.、Belalov I.S.、Matyushkina D.M.、Ivanov P.A.、Kulikov E.E.、Kostrukova E.S.、Clokie M.R.J.C.、Letarova M.A.、Manolov A.I.、Prilipov A.G.、Babenko V.V.、Letarov A.V.
Winogradsky Institute of Microbiology RC Biotechnology RASWinogradsky Institute of Microbiology RC Biotechnology RASDepartment of Bioengineering and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-ChampaignWinogradsky Institute of Microbiology RC Biotechnology RASFederal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological AgencyWinogradsky Institute of Microbiology RC Biotechnology RAS||The Mental Health Research CenterWinogradsky Institute of Microbiology RC Biotechnology RASFederal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological AgencyDepartment of Infection, Immunity and Inflammation, University of LeicesterWinogradsky Institute of Microbiology RC Biotechnology RASFederal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological AgencyN. F. Gamaleya Federal Center of Epidemiology and Microbiology, Ministry of Health of the Russian FederationFederal Research and Clinical Center of Physical-Chemical Medicine, Federal Medical Biological AgencyWinogradsky Institute of Microbiology RC Biotechnology RAS||Faculty of Biology, Lomonosov Moscow State University
微生物学分子生物学环境生物学
Golomidova A.K.,Prokhorov N.S.,Maslov S.,Belalov I.S.,Matyushkina D.M.,Ivanov P.A.,Kulikov E.E.,Kostrukova E.S.,Clokie M.R.J.C.,Letarova M.A.,Manolov A.I.,Prilipov A.G.,Babenko V.V.,Letarov A.V..Phages associated with horses provide new insights into the dominance of lateral gene transfer in virulent bacteriophages evolution in natural systems[EB/OL].(2025-03-28)[2025-05-29].https://www.biorxiv.org/content/10.1101/542787.点此复制
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