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On the principles of cell decision-making: intracellular coupling improves cell responses fidelity of noisy signals

On the principles of cell decision-making: intracellular coupling improves cell responses fidelity of noisy signals

来源:bioRxiv_logobioRxiv
英文摘要

Reliability of cell fate decision-making is crucial to biological development. Until today it has not been clear what are biology’s design principles that allow for reliable cell decision making under the influence of noise. Here, we attempt to answer this question by drawing an analogy between cell decision-making and information theory. We show that coupling of intracellular signalling pathway networks makes cell phenotypic responses reliable for noisy signals. As a proof of concept, we show how cis-interaction of the Notch-Delta pathway allows for increased performance under the influence of noise. Interestingly, in this case, the coupling principle leads to an efficient energy management. Finally, our postulated principle offers a compelling argument why cellular encoding is organized in a non-linear and non-hierarchical manner.

Reppas Andreas I.、Jorswieck Eduard A.、Hatzikirou Haralampos

Helmholtz Centre for Infection ResearchFaculty of Electrical and Computer Engineering Communications Laboratory, Communications Theory, Technische Universit?t DresdenHelmholtz Centre for Infection Research

10.1101/125864

细胞生物学分子生物学生物科学理论、生物科学方法

Reppas Andreas I.,Jorswieck Eduard A.,Hatzikirou Haralampos.On the principles of cell decision-making: intracellular coupling improves cell responses fidelity of noisy signals[EB/OL].(2025-03-28)[2025-06-08].https://www.biorxiv.org/content/10.1101/125864.点此复制

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