A Connectome and Analysis of the Adult Drosophila Central Brain
A Connectome and Analysis of the Adult Drosophila Central Brain
Abstract The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster. Improved methods include new procedures to prepare, image, align, segment, find synapses in, and proofread such large data sets. We define cell types, refine computational compartments, and provide an exhaustive atlas of cell examples and types, many of them novel. We provide detailed circuits consisting of neurons and their chemical synapses for most of the central brain. We make the data public and simplify access, reducing the effort needed to answer circuit questions, and provide procedures linking the neurons defined by our analysis with genetic reagents. Biologically, we examine distributions of connection strengths, neural motifs on different scales, electrical consequences of compartmentalization, and evidence that maximizing packing density is an important criterion in the evolution of the fly’s brain.
Smith Kelsey、Bailey Dennis A.、Duclos Octave、Tokhi Temour、Rymer Jon Thomson、Jain Viren、Bogovic John、Xu C. Shan、Takemura Shin-ya、Maitin-Shepard Jeremy、Berg Stuart、Clements Jody、Blakely Tim、Dolafi Tom、Kawase Takashi、Ackerman David、Schlegel Philipp、Shinomiya Aya、Suleiman Alia、Swift Jackie、Takemura Satoko、Talebi Iris、Tenshaw Emily、Walsh John J.、Horne Jane Anne、Parekh Ruchi、Jayaraman Vivek、Rubin Gerald M.、Hess Harald F.、Shinomiya Kazunori、Joyce Emily M.、Otsuna Hideo、Trautman Eric T.、Goldammer Jens、Svirskas Robert、Alvarado Chelsea X.、Ballinger Samantha、Cheatham Natasha、Dreher Marisa、Eubanks Bryon、Fairbanks Kelli、Hopkins Gary Patrick、Kovalyak Julie、Lauchie Shirley A.、Lohff Alanna、Maldonado Charli、Phillips Emily M.、Ribeiro Caitlin、Sammons Megan、Zhao Ting、Khairy Khaled A.、Manley Emily A.、Mooney Caroline、Ogundeyi Omotara、Okeoma Nneoma、Patrick Christopher、Paterson Tyler、Forknall Nora、Meinertzhagen Ian A.、Li Peter H.、Hubbard Philip、Francis Audrey、Neace Erika R.、Kainmueller Dagmar、Borycz Jolanta A、Cook Michael、Leavitt Laramie、Olbris Donald J.、Scott Anne K.、Ryan Sean M.、Padilla Nicholas、Katz William、Finley Samantha、Robertson Madelaine K、Kim SungJin、Ordish Christopher、Scott Ashley L.、Huang Gary B.、Neubarth Nicole、Knecht Christopher J. Jr.、Saalfeld Stephan、Ito Kei、Umayam Lowell、Ito Masayoshi、George Reed、Kirk Nicole A.、Plaza Stephen M.、McLin Sari、Rampally Neha、Yang Tansy、Tarnogorska Dorota、Lindsey Larry、Scheffer Louis K.、Wolff Tanya、Rivlin Patricia K.、Smith Natalie L.、Smith Claire、Ndama Miatta、Canino Brandon S.、Januszewski Michal、Lu Zhiyuan、Phillips Elliott E.、Sobeski Margaret A.、Hayworth Kenneth J.、Li Feng
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生物科学研究方法、生物科学研究技术昆虫学细胞生物学
Smith Kelsey,Bailey Dennis A.,Duclos Octave,Tokhi Temour,Rymer Jon Thomson,Jain Viren,Bogovic John,Xu C. Shan,Takemura Shin-ya,Maitin-Shepard Jeremy,Berg Stuart,Clements Jody,Blakely Tim,Dolafi Tom,Kawase Takashi,Ackerman David,Schlegel Philipp,Shinomiya Aya,Suleiman Alia,Swift Jackie,Takemura Satoko,Talebi Iris,Tenshaw Emily,Walsh John J.,Horne Jane Anne,Parekh Ruchi,Jayaraman Vivek,Rubin Gerald M.,Hess Harald F.,Shinomiya Kazunori,Joyce Emily M.,Otsuna Hideo,Trautman Eric T.,Goldammer Jens,Svirskas Robert,Alvarado Chelsea X.,Ballinger Samantha,Cheatham Natasha,Dreher Marisa,Eubanks Bryon,Fairbanks Kelli,Hopkins Gary Patrick,Kovalyak Julie,Lauchie Shirley A.,Lohff Alanna,Maldonado Charli,Phillips Emily M.,Ribeiro Caitlin,Sammons Megan,Zhao Ting,Khairy Khaled A.,Manley Emily A.,Mooney Caroline,Ogundeyi Omotara,Okeoma Nneoma,Patrick Christopher,Paterson Tyler,Forknall Nora,Meinertzhagen Ian A.,Li Peter H.,Hubbard Philip,Francis Audrey,Neace Erika R.,Kainmueller Dagmar,Borycz Jolanta A,Cook Michael,Leavitt Laramie,Olbris Donald J.,Scott Anne K.,Ryan Sean M.,Padilla Nicholas,Katz William,Finley Samantha,Robertson Madelaine K,Kim SungJin,Ordish Christopher,Scott Ashley L.,Huang Gary B.,Neubarth Nicole,Knecht Christopher J. Jr.,Saalfeld Stephan,Ito Kei,Umayam Lowell,Ito Masayoshi,George Reed,Kirk Nicole A.,Plaza Stephen M.,McLin Sari,Rampally Neha,Yang Tansy,Tarnogorska Dorota,Lindsey Larry,Scheffer Louis K.,Wolff Tanya,Rivlin Patricia K.,Smith Natalie L.,Smith Claire,Ndama Miatta,Canino Brandon S.,Januszewski Michal,Lu Zhiyuan,Phillips Elliott E.,Sobeski Margaret A.,Hayworth Kenneth J.,Li Feng.A Connectome and Analysis of the Adult Drosophila Central Brain[EB/OL].(2025-03-28)[2025-07-01].https://www.biorxiv.org/content/10.1101/2020.04.07.030213.点此复制
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