Computational Properties of the Visual Microcircuit
Computational Properties of the Visual Microcircuit
Abstract The neocortex is organized around layered microcircuits consisting of a variety of excitatory and inhibitory neuronal types which perform rate-and oscillation based computations. Using modeling, we show that both superficial and deep layers of the primary mouse visual cortex implement two ultrasensitive and bistable switches built on mutual inhibitory connectivity motives between SST, PV and VIP cells. The switches toggle pyramidal neurons between high and low firing rate states that are synchronized across layers through translaminar connectivity. Moreover, inhibited and disinhibited states are characterized by low- and high frequency oscillations, respectively, with layer-specific differences in frequency and power which show asymmetric changes during state transitions. These findings are consistent with a number of experimental observations and embed firing rate together with oscillatory changes within a switch interpretation of the microcircuit.
Kumar Arvind、Schmidt Helmut、Kn?sche Thomas R.、Hahn Gerald、Deco Gustavo
Computational Science and Technology, School of Electrical Engineering and Computer ScienceMax Planck Institute for Human Cognitive and Brain SciencesMax Planck Institute for Human Cognitive and Brain Sciences||Institute of Biomedical Engineering and Informatics, Department of Computer Science and Automation, Technische Universit?t IlmenauCenter for Brain and Cognition, Computational Neuroscience Group, Department of Information and Communication Technologies, Universitat Pompeu FabraCenter for Brain and Cognition, Computational Neuroscience Group, Department of Information and Communication Technologies, Universitat Pompeu Fabra||Instituci¨? Catalana de la Recerca i Estudis Avan?ats||Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences||School of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University
生物物理学生物科学现状、生物科学发展生物科学研究方法、生物科学研究技术
Kumar Arvind,Schmidt Helmut,Kn?sche Thomas R.,Hahn Gerald,Deco Gustavo.Computational Properties of the Visual Microcircuit[EB/OL].(2025-03-28)[2025-06-29].https://www.biorxiv.org/content/10.1101/2020.07.30.229435.点此复制
评论