Waning antibody levels after vaccination with mRNA BNT162b2 and inactivated CoronaVac COVID-19 vaccines in Hong Kong blood donors
Waning antibody levels after vaccination with mRNA BNT162b2 and inactivated CoronaVac COVID-19 vaccines in Hong Kong blood donors
Abstract Both inactivated vaccine (CoronaVac; Sinovac) and mRNA vaccine (Comirnaty/BNT162b2; Fosun-Pharma/BioNTech) are available in Hong Kong’s COVID-19 Vaccination Programme. We reported waning antibody levels by enzyme-linked immunosorbent assays (ELISA) and surrogate virus neutralization test (sVNT) among 850 fully vaccinated blood donors (i.e., received two doses). The BNT162b2 group’s antibody levels remain over the 50% protection threshold within six months, and the CoronaVac’s group’s median antibody levels begin to fall below the 50% protection threshold two months after vaccination.
Leung Jennifer NS、Kwok Shirley LL、Lee Cheuk-Kwong、Wu Joseph T、Leung Kathy、Peiris JS Malik、Cheng Samuel MS
Hong Kong Red Cross Blood Transfusion Service, Hospital AuthorityWHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong||Laboratory of Data Discovery for Health (D24H)Hong Kong Red Cross Blood Transfusion Service, Hospital AuthorityWHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong||Laboratory of Data Discovery for Health (D24H)WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong||Laboratory of Data Discovery for Health (D24H)WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong||HKU-Pasteur Research Pole, School of Public Health, The University of Hong Kong||Centre for Immunology and Infection (C2i), Hong Kong Science ParkWHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, LKS Faculty of Medicine, The University of Hong Kong||HKU-Pasteur Research Pole, School of Public Health, The University of Hong Kong||Centre for Immunology and Infection (C2i), Hong Kong Science Park
预防医学生物科学现状、生物科学发展生物科学研究方法、生物科学研究技术
Leung Jennifer NS,Kwok Shirley LL,Lee Cheuk-Kwong,Wu Joseph T,Leung Kathy,Peiris JS Malik,Cheng Samuel MS.Waning antibody levels after vaccination with mRNA BNT162b2 and inactivated CoronaVac COVID-19 vaccines in Hong Kong blood donors[EB/OL].(2025-03-28)[2025-05-17].https://www.medrxiv.org/content/10.1101/2021.12.05.21267330.点此复制
评论