Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

作者：Kanetsky Peter A.、Gillanders Elizabeth M.、Goldstein Alisa M.、Hansson Johan、Helsing Per、H?iom Veronica、Mackie Rona M.、Mann Graham J.、Molven Anders、Puig Susana、L. Radford-Smith Graham、Craig Jamie E.、Duffy David L.、Li Xin、Jacobs Leonie C.、Evans David M.、Barrett Jennifer H.、MacGregor Stuart、Hewitt Alex W.、Kayser Manfred、Hunter David J.、Smith George Davey、Lee Jeffrey E.、Swerdlow Anthony J.、Kypreou Katerina P.、Harland Mark、Wright Margaret J.、Glass Dan、Ikram Arfan M.、Uitterlinden Andr¨| G.、Brossard Myriam、Azizi Esther、Elder David E.、Simms Lisa A.、Pooley Karen A.、Cust Anne E.、Schulze Hans-Joachim、Dunning Alison M.、Kraft Peter、Amos Christopher I.、Bishop D. Timothy、Iles Mark、Avril Marie-Fran?oise、Chen Wei V.、Beesley Jonathan、Henders Anjali K.、van Doorn Remco、Landi Maria Teresa、Heath Andrew C.、Lang Julie、Galan Pilar、Easton Douglas F.、Kumar Rajiv、Nijsten Tamar E.、Novakovi? Srdjan、van der Stoep Nienke、Brown Kevin M.、D?bniak Tadeusz、Law Matthew、Chanock Stephen、Lathrop G. Mark、Schadendorf Dirk、Burdon Kathryn P.、Lubi¨?ski Jan、Sanna Marianna、Lui Fan、Sturm Richard A.、Whiteman David C.、Ward Sarah V.、Bataille Veronique、Nelson Elliot C.、Gruis Nelleke A.、Yazar Seyhan、Andresen Per A.、Ho?evar Marko、Scarr¨¤ Giovanna Bianchi、Friedman Eitan、Han Jiali、Zhu Gu、Bishop Julia A. Newton、Li Xin、Pharoah Paul D. P.、Moses Eric K.、Ingvar Christian、Melanoma GWAS Consortium、Demenais Florence、Taylor John C.、Ghiorzo Paola、Hayward Nicholas K.、Song Fengju、Spector Timothy D.、Nyholt Dale R.、Fang Shenying、Martin Nicholas G.、Orr Nicholas、Brown Matthew A.、Madden Pamela A.、Bowdler Lisa、Visconti Alessia、Montgomery Grant W.、Mackey David A.、Stratigos Alexander J.、Puig-Butille Joan Anton、Olsson H?kan、Green Adele C.、Falchi Mario、Akslen Lars A.、Randerson-Moor Juliette

作者单位：Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research InstituteInherited Disease Research Branch, National Human Genome Research Institute, National Institutes of HealthDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of HealthDepartment of Oncology-Pathology, Karolinska Institutet, Karolinska University HospitalDepartment of Dermatology, Oslo University Hospital, RikshospitaletDepartment of Oncology-Pathology, Karolinska Institutet, Karolinska University HospitalDepartment of Public Health, University of GlasgowCentre for Cancer Research, University of Sydney at Westmead, Millennium Institute for Medical Research and Melanoma Institute AustraliaDepartment of Pathology, Haukeland University HospitalMelanoma Unit, Dermatology Department & Biochemistry and Molecular Genetics Departments, Hospital Clinic, Institut de Investigac¨? Biom¨¨dica August Pi Su?e, Universitat de BarcelonaInflammatory Bowel Diseases, QIMR Berghofer Medical Research InstituteDepartment of Ophthalmology, Flinders UniversityQIMR Berghofer Medical Research InstituteHarvard T.H. Chan School of Public HealthDepartment of Dermatology, Erasmus MC, University Medical CentreMRC Integrative Epidemiology Unit, University of Bristol||University of Queensland Diamantina Institute, Translational Research InstituteSection of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of LeedsQIMR Berghofer Medical Research InstituteCentre for Ophthalmology and Vision Science, University of Western Australia and the Lions Eye InstituteDepartment of Genetic Identification, Erasmus MC, University Medical CentreHarvard T.H. Chan School of Public HealthMRC Integrative Epidemiology Unit, University of BristolDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer CenterDivision of Genetics and Epidemiology, The Institute of Cancer ResearchDepartment of Dermatology, University of Athens School of MedicineSection of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of LeedsQIMR Berghofer Medical Research InstituteDepartment of Twin Research & Genetic EpidemiologyDepartment of EpidemiologyDepartment of Internal MedicineInstitut National de la Sant¨| et de la Recherche M¨|dicale (INSERM), UMR-946, Genetic Variation and Human Diseases UnitDepartment of Dermatology, Sheba Medical Center, Tel Hashomer, Sackler Faculty of MedicineDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of PennsylvaniaDepartment of Clinical Genetics, Leiden University Medical CenterCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of CambridgeCancer Epidemiology and Services Research, Sydney School of Public Health, The University of Sydney||Present address: Sydney School of Public Health and the Melanoma Institute Australia, University of SydneyDepartment of Dermatology, Fachklinik Hornheide, Institute for Tumors of the Skin at the University of M¨1nsterCentre for Cancer Genetic Epidemiology, Department of Oncology, University of CambridgeHarvard T.H. Chan School of Public HealthDepartment of Community and Family Medicine, Geisel School of Medicine, Dartmouth CollegeSection of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of LeedsSection of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of LeedsAssistance Publique¨CH?pitaux de Paris, H?pital Cochin, Service de Dermatologie, Universit¨| Paris DescartesDepartment of Genetics, The University of Texas MD Anderson Cancer CenterQIMR Berghofer Medical Research InstituteQIMR Berghofer Medical Research Institute||Present address: Institute for Molecular Bioscience, The University of QueenslandDepartment of Dermatology, Leiden University Medical CentreDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of HealthDepartment of Psychiatry, Washington University School of MedicineDepartment of Medical Genetics, University of GlasgowUniversit¨| Paris 13, Equipe de Recherche en Epid¨|miologie Nutritionnelle (EREN), Centre de Recherche en Epid¨|miologie et Statistiques, Institut National de la Sant¨| et de la Recherche M¨|dicale (INSERM U1153), Institut National de la Recherche Agronomique (INRA U1125), Conservatoire National des Arts et M¨|tiers, Communaut¨| ?Universit¨| Sorbonne Paris Cit¨|Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of CambridgeDivision of Molecular Genetic Epidemiology, German Cancer Research CenterDepartment of Dermatology, Erasmus MC, University Medical CentreDepartment of Molecular Diagnostics, Institute of Oncology LjubljanaDepartment of Clinical Genetics, Leiden University Medical CenterDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of HealthInternational Hereditary Cancer Center, Pomeranian Medical UniversityQIMR Berghofer Medical Research InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteMcGill University and Genome Quebec Innovation CentreDepartment of Dermatology, University Hospital EssenMenzies Institute for Medical Research, University of Tasmania, HobartInternational Hereditary Cancer Center, Pomeranian Medical UniversityDepartment of Twin Research & Genetic EpidemiologyDepartment of Genetic Identification, Erasmus MC, University Medical CentreDermatology Research Centre, University of Queensland Diamantina Institute, Translational Research InstituteCancer Control Group, QIMR Berghofer Medical Research InstituteCentre for Genetic Origins of Health and Disease, Faculty of Medicine, Dentistry and Health Sciences, The University of Western Australia||Present address: Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer CenterDepartment of Twin Research & Genetic EpidemiologyDepartment of Psychiatry, Washington University School of MedicineDepartment of Dermatology, Leiden University Medical CentreCentre for Ophthalmology and Vision Science, University of Western Australia and the Lions Eye InstituteDepartment of Pathology, Molecular Pathology, Oslo University HospitalDepartment of Surgical Oncology, Institute of Oncology LjubljanaDepartment of Internal Medicine and Medical Specialties, University of GenoaOncogenetics Unit, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv UniversityDepartment of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, Indiana UniversityQIMR Berghofer Medical Research InstituteSection of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of LeedsDepartment of Dermatology, The Warren Alpert Medical School of Brown UniversityCentre for Cancer Genetic Epidemiology, Department of Oncology, University of CambridgeCentre for Genetic Origins of Health and Disease, Faculty of Medicine, Dentistry and Health Sciences, The University of Western AustraliaDepartment of Surgery, Clinical Sciences, Lund UniversityInstitut National de la Sant¨| et de la Recherche M¨|dicale (INSERM), UMR-946, Genetic Variation and Human Diseases UnitSection of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of LeedsDepartment of Internal Medicine and Medical Specialties, University of GenoaQIMR Berghofer Medical Research InstituteDepartments of Epidemiology and Biostatistics, Key Laboratory of Cancer Prevention and Therapy, Tianjin, National Clinical Research Center of Cancer, Tianjin Medical University Cancer Institute and HospitalDepartment of Twin Research & Genetic EpidemiologyInstitute of Health and Biomedical Innovation, Queensland University of TechnologyDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer CenterQIMR Berghofer Medical Research InstituteBreakthrough Breast Cancer Research Centre, The Institute of Cancer ResearchUniversity of Queensland Diamantina Institute, Translational Research InstituteDepartment of Psychiatry, Washington University School of MedicineQIMR Berghofer Medical Research InstituteDepartment of Twin Research & Genetic EpidemiologyQIMR Berghofer Medical Research Institute||Present address: Institute for Molecular Bioscience, The University of QueenslandCentre for Ophthalmology and Vision Science, University of Western Australia and the Lions Eye InstituteDepartment of Dermatology, University of Athens School of MedicineMelanoma Unit, Dermatology Department & Biochemistry and Molecular Genetics Departments, Hospital Clinic, Institut de Investigac¨? Biom¨¨dica August Pi Su?e, Universitat de BarcelonaDepartment of Oncology/Pathology, Clinical Sciences, Lund UniversityQIMR Berghofer Medical Research Institute||Molecular Oncology Group, CRUK Manchester Institute, University of ManchesterDepartment of Twin Research & Genetic EpidemiologyCentre for Cancer Biomarkers CCBIO, Department of Clinical Medicine, University of BergenSection of Epidemiology and Biostatistics, Leeds Institute of Cancer and Pathology, University of Leeds

DOI：10.1101/173112

学科分类：肿瘤学皮肤病学、性病学基础医学

推荐引用：Kanetsky Peter A.,Gillanders Elizabeth M.,Goldstein Alisa M.,Hansson Johan,Helsing Per,H?iom Veronica,Mackie Rona M.,Mann Graham J.,Molven Anders,Puig Susana,L. Radford-Smith Graham,Craig Jamie E.,Duffy David L.,Li Xin,Jacobs Leonie C.,Evans David M.,Barrett Jennifer H.,MacGregor Stuart,Hewitt Alex W.,Kayser Manfred,Hunter David J.,Smith George Davey,Lee Jeffrey E.,Swerdlow Anthony J.,Kypreou Katerina P.,Harland Mark,Wright Margaret J.,Glass Dan,Ikram Arfan M.,Uitterlinden Andr¨| G.,Brossard Myriam,Azizi Esther,Elder David E.,Simms Lisa A.,Pooley Karen A.,Cust Anne E.,Schulze Hans-Joachim,Dunning Alison M.,Kraft Peter,Amos Christopher I.,Bishop D. Timothy,Iles Mark,Avril Marie-Fran?oise,Chen Wei V.,Beesley Jonathan,Henders Anjali K.,van Doorn Remco,Landi Maria Teresa,Heath Andrew C.,Lang Julie,Galan Pilar,Easton Douglas F.,Kumar Rajiv,Nijsten Tamar E.,Novakovi? Srdjan,van der Stoep Nienke,Brown Kevin M.,D?bniak Tadeusz,Law Matthew,Chanock Stephen,Lathrop G. Mark,Schadendorf Dirk,Burdon Kathryn P.,Lubi¨?ski Jan,Sanna Marianna,Lui Fan,Sturm Richard A.,Whiteman David C.,Ward Sarah V.,Bataille Veronique,Nelson Elliot C.,Gruis Nelleke A.,Yazar Seyhan,Andresen Per A.,Ho?evar Marko,Scarr¨¤ Giovanna Bianchi,Friedman Eitan,Han Jiali,Zhu Gu,Bishop Julia A. Newton,Li Xin,Pharoah Paul D. P.,Moses Eric K.,Ingvar Christian,Melanoma GWAS Consortium,Demenais Florence,Taylor John C.,Ghiorzo Paola,Hayward Nicholas K.,Song Fengju,Spector Timothy D.,Nyholt Dale R.,Fang Shenying,Martin Nicholas G.,Orr Nicholas,Brown Matthew A.,Madden Pamela A.,Bowdler Lisa,Visconti Alessia,Montgomery Grant W.,Mackey David A.,Stratigos Alexander J.,Puig-Butille Joan Anton,Olsson H?kan,Green Adele C.,Falchi Mario,Akslen Lars A.,Randerson-Moor Juliette.Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways[EB/OL].(2025-03-28)[2025-05-08].https://www.biorxiv.org/content/10.1101/173112.点此复制