Co-circulation of multiple influenza A variants in swine harboring genes from seasonal human and swine influenza viruses
Co-circulation of multiple influenza A variants in swine harboring genes from seasonal human and swine influenza viruses
Abstract Since the influenza pandemic in 2009, there has been an increased focus on swine influenza A virus (swIAV) surveillance. This paper describes the results of the surveillance of swIAV in Danish swine from 2011 to 2018. In total, 3800 submissions were received with a steady increase in swIAV positive submissions, reaching 56% in 2018. Ten different swIAV subtypes were detected. Full genome sequences were obtained from 129 swIAV positive samples. Altogether, 17 different circulating genotypes were identified including novel reassortants and subtypes harboring human seasonal IAV gene segments. The phylogenetic analysis revealed substantial genetic drift and also evidence of positive selection occurring mainly in antigenic sites of the hemagglutinin protein and confirmed the presence of a swine divergent cluster among the H1pdm09Nx viruses. The results provide essential data for the control of swIAV in pigs and for early detection of novel swIAV strains with zoonotic potential.
Krog Jesper Schak、?stergaard Breum Solvej、Pedersen Anders Gorm、Trebbien Ramona、Larsen Lars Erik、Hjulsager Charlotte Kristiane、Ryt-Hansen Pia
Statens Serum InstitutStatens Serum InstitutDepartment of Health Technology, Section for Bioinformatics, Technical University of DenmarkStatens Serum InstitutTechnical University of Denmark, National Veterinary Institute||University of Copenhagen, Department of Health Sciences, Institute for Animal and Veterinary SciencesStatens Serum InstitutTechnical University of Denmark, National Veterinary Institute||University of Copenhagen, Department of Health Sciences, Institute for Animal and Veterinary Sciences
医药卫生理论医学研究方法微生物学
Krog Jesper Schak,?stergaard Breum Solvej,Pedersen Anders Gorm,Trebbien Ramona,Larsen Lars Erik,Hjulsager Charlotte Kristiane,Ryt-Hansen Pia.Co-circulation of multiple influenza A variants in swine harboring genes from seasonal human and swine influenza viruses[EB/OL].(2025-03-28)[2025-05-23].https://www.biorxiv.org/content/10.1101/2020.07.28.225706.点此复制
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