Knowledge mobilization activities to support decision-making by youth, parents, and adults using a systematic and living map of evidence and recommendations on COVID-19: protocol for a randomized controlled trial
Knowledge mobilization activities to support decision-making by youth, parents, and adults using a systematic and living map of evidence and recommendations on COVID-19: protocol for a randomized controlled trial
Abstract IntroductionThe COVID-19 pandemic underlined that guidelines and recommendations must be made more accessible and more understandable to the general public, including adults, parents, and youth, to improve health outcomes. The objective of this study is to the public’s (youth, parents, and adult populations) understanding, usability, satisfaction, intention to implement, and preference for different ways of presenting COVID-19 health recommendations derived from the COVID-19 Living Map of Recommendations and Gateway to Contextualization (herein referred to as the RecMap). Methods and AnalysisThis is a protocol for a mixed-methods study. We will conduct a pragmatic allocation-concealed, blinded superiority randomized controlled trial (RCT) in three populations: adults (21 years of age or older), parents (18 years or above and are a parent or legal guardian of a child under 18 years old), and youth (15 to 24 years old), with at least 240 participants in each population. The trial will consist of an online survey and optional one on one interview. Prior to initiating the RCT, all PLRs were refined with relevant stakeholder input. In each population group, the intervention arm will receive a PLR format while the control arm will receive the original recommendation format as originally published by the guideline organizations (herein referred to as Standard Language Version). Our primary outcome is understanding, and our secondary outcomes are accessibility and usability, satisfaction, intended behavior, and preference for the two recommendation formats. Each population’s results will be analyzed separately. We will pool the results across populations using meta-analysis, and also explore potential interaction and subgroup effects within each population. At the end of each survey, participants will be invited to participate in a one-on-one semi-structured interview to explore reasons for their choices and learn for future research. All interviews will be analyzed using thematic analysis. Interpretation will be iterative as data coding proceeds. Ethics and DisseminationThrough Clinical Trials Ontario (CTO), the Hamilton Integrated Research Ethics Board has reviewed and approved this protocol (Project ID: 3856). The University of Alberta will also be submitting for ethics approval. All potential participants will be required to provide informed consent. The findings from this study will be disseminated through open-access publications in peer-reviewed journals. Strengths and limitations of this studyWe are following a mixed methods approach: randomized controlled trial and qualitative interviews. The qualitative results will supplement and help explain our quantitative findings.This protocol is reported in accordance with the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT), which enhances transparency and completeness. The trial uses previously validated outcomes from similar trials. This will strengthen the credibility of our results.Our study is testing an evaluated PLR format, which makes our intervention stronger, and is recruiting internationally, which ensures the inclusion of a diverse population.Recruitment will take place online using social media, and data will be collected using an online survey. This allows for self-selection and limits accessibility to those who have no or limited digital access, which in turn limits generalizability.While the recommendations are offered in multiple languages through the RecMap, the study is only testing English Plain Language Recommendations.
Offringa Martin、Munan Matthew、Elliott Sarah、Mathew Joseph L.、Akl Elie A.、Kredo Tamara、Relihan Jacqueline、Suvada Jozef、Stevens Adrienne、Sch¨1nemann Holger J.、Baba Ami、Klugar Miloslav、Pottie Kevin、Falavigna Maicon、Lotfi Tamara、Richards Dawn P.、Prebeg Matthew、Charide Rana、Stallwood Lisa、Sayfi Shahab、Motillal Ashley、Scott Shannon D.、Hartling Lisa、Butcher Nancy J.
Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute||Institute of Health Policy, Management and Evaluation, University of Toronto||Division of Neonatology, The Hospital for Sick ChildrenAlberta Research Centre for Health Evidence, Department of Pediatrics, Faculty of Medicine and Dentistry, University of AlbertaAlberta Research Centre for Health Evidence, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta||Cochrane Child Health, Department of Pediatrics, University of AlbertaPostgraduate Institute of Medical Education and ResearchDepartment of Health Research Methods, Evidence and Impact, McMaster University||Department of Internal Medicine, American University of BeirutCochrane South Africa, South African Medical Research Council||Division of Clinical Pharmacology, Department of Medicine and Division of Epidemiology and Biostatistics, Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch UniversityCentre for Addiction and Mental HealthDepartments of Science and International Studies, St. Elizabeth University of Public Health and Social ScienceDepartment of Health Research Methods, Evidence and Impact, McMaster University||Michael G. DeGroote Cochrane Canada and McMaster GRADE Centres, McMaster UniversityDepartment of Health Research Methods, Evidence and Impact, McMaster University||Michael G. DeGroote Cochrane Canada and McMaster GRADE Centres, McMaster UniversityChild Health Evaluative Sciences, The Hospital for Sick Children Research InstituteCzech National Centre for Evidence-Based Healthcare and Knowledge Translation (Cochrane Czech Republic, Czech EBHC: JBI Centre of Excellence, Masaryk University GRADE Centre), Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk UniversitySchulich School of Medicine & Dentistry, Western University||Department of Family Medicine, Western UniversityNational Institute for Health Technology Assessment, Federal University of Rio Grande do SulDepartment of Health Research Methods, Evidence and Impact, McMaster University||Michael G. DeGroote Cochrane Canada and McMaster GRADE Centres, McMaster UniversityFive02 Labs Inc||Canadian Arthritis Patient AllianceCentre for Addiction and Mental HealthDepartment of Health Research Methods, Evidence and Impact, McMaster UniversityChild Health Evaluative Sciences, The Hospital for Sick Children Research InstituteSchulich School of Medicine & Dentistry, Western UniversityDepartment of Health Research Methods, Evidence and Impact, McMaster University||Michael G. DeGroote Cochrane Canada and McMaster GRADE Centres, McMaster UniversityFaculty of Nursing, University of AlbertaAlberta Research Centre for Health Evidence, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta||Cochrane Child Health, Department of Pediatrics, University of AlbertaChild Health Evaluative Sciences, The Hospital for Sick Children Research Institute||Department of Psychiatry, University of Toronto
医学研究方法预防医学
Offringa Martin,Munan Matthew,Elliott Sarah,Mathew Joseph L.,Akl Elie A.,Kredo Tamara,Relihan Jacqueline,Suvada Jozef,Stevens Adrienne,Sch¨1nemann Holger J.,Baba Ami,Klugar Miloslav,Pottie Kevin,Falavigna Maicon,Lotfi Tamara,Richards Dawn P.,Prebeg Matthew,Charide Rana,Stallwood Lisa,Sayfi Shahab,Motillal Ashley,Scott Shannon D.,Hartling Lisa,Butcher Nancy J..Knowledge mobilization activities to support decision-making by youth, parents, and adults using a systematic and living map of evidence and recommendations on COVID-19: protocol for a randomized controlled trial[EB/OL].(2025-03-28)[2025-05-09].https://www.medrxiv.org/content/10.1101/2022.05.09.22274842.点此复制
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