Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID)
Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID)
Abstract PHOSP-COVID is a national UK multi-centre cohort study of patients who were hospitalised for COVID-19 and subsequently discharged.PHOSP-COVID was established to investigate the medium- and long-term sequelae of severe COVID-19 requiring hospitalisation, understand the underlying mechanisms of these sequelae, evaluate the medium- and long-term effects of COVID-19 treatments, and to serve as a platform to enable future studies, including clinical trials.Data collected covered a wide range of physical measures, biological samples, and Patient Reported Outcome Measures (PROMs).Participants could join the cohort either in Tier 1 only with remote data collection using hospital records, a PROMs app and postal saliva sample for DNA, or in Tier 2 where they were invited to attend two specific research visits for further data collection and biological research sampling. These research visits occurred at five (range 2-7) months and 12 (range 10-14) months post-discharge. Participants could also participate in specific nested studies (Tier 3) at selected sites.All participants were asked to consent to further follow-up for 25 years via linkage to their electronic healthcare records and to be re-contacted for further research.In total, 7935 participants were recruited from 83 UK sites: 5238 to Tier 1 and 2697 to Tier 2, between August 2020 and March 2022.Cohort data are held in a Trusted Research Environment and samples stored in a central biobank. Data and samples can be accessed upon request and subject to approvals.
Kerr Steven、Briggs Andrew、Rowland-Jones Sarah L、Jolley Caroline、Poinasamy Krisnah、Raman Betty、Shikotra Aarti、Sereno Marco、Saunders Ruth M、Greening Neil J、Quint Jennifer K、Lone Nazir I、Thorpe Mathew、Heaney Liam G、Bolton Charlotte E、Diar Bakerly Nawar、Easom Nicholas、Fuld Jonathan、Hart Nick、Pfeffer Paul、Thompson AA Roger、Chalder Trudie、Greenhalf William、Heller Simon、Jacob Joseph、Man William D-C、Porter Joanna C、Scott Janet T、Thomas David C、Sheikh Aziz、Aul Raminder、Elneima Omer、Docherty Annemarie B、Hurst John R、De Soyza Anthony、Harris Victoria C、Rowland Matthew J、McAuley Hamish J C、Singapuri Amisha、Jenkins R Gisli、Beirne Paul、Jones Mark G、Brightling Christopher E、Neubauer Stefan、Chalmers James D、Lewis Keir E、Singh Sally J、Semple Malcolm G、Ho Ling-Pei、Shah Ajay M、Choudhury Gourab、Toshner Mark、Openshaw Peter JM、Geddes John R、Marks Michael、McCann Gerry P、Brown Jeremy S、Harrison Ewen M、Howard Luke S、Houchen-Wolloff Linzy、Horsley Alex、Evans Rachael A、Echevarria Carlos、Richardson Matthew、Leavy Olivia C、Wootton Dan G、Davies Melanie J、Rahman Najib M、Parekh Dhruv、Wain Louise V、Lord Janet M
Centre for Medical Informatics, The Usher Institute||The Roslin Institute, University of EdinburghLondon School of Hygiene & Tropical MedicineUniversity of Sheffield||Sheffield Teaching Hospitals NHS Foundation TrustCentre for Human & Applied Physiological Sciences, School of Basic & Medical Biosciences||King?ˉs College Hospital NHS Foundation TrustAsthma and Lung UKOxford University Hospitals NHS Foundation Trust||Division of Cardiovascular Medicine, Radcliffe Department of MedicineThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre-RespiratoryThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre-RespiratoryThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre-RespiratoryThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre-RespiratoryNational Heart and Lung InstituteCentre for Medical Informatics, The Usher Institute||Royal Infirmary of Edinburgh, NHS LothianCentre for Medical Informatics, The Usher InstituteWellcome-Wolfson Institute for Experimental Medicine||Belfast Health & Social Care TrustNottingham University Hospitals NHS Trust||NIHR Nottingham Biomedical Research CentreManchester Metropolitan University||Salford Royal NHS Foundation TrustInfection Research Group||University of HullDepartment of Respiratory Medicine||NIHR Cambridge Clinical Research FacilityLane Fox Respiratory Unit, Guy?ˉs and St Thomas?ˉ NHS Foundation TrustDepartment of Respiratory Medicine, Barts Health NHS Trust||Barts and The London School of Medicine and DentistryUniversity of Sheffield||Sheffield Teaching Hospitals NHS Foundation TrustDepartment of Psychological Medicine, Institute of Psychiatry||South London and Maudsley NHS Foundation TrustLiverpool University Hospitals NHS Foundation Trust||The CRUK Liverpool Experimental Cancer Medicine CentreDepartment of Oncology and Metabolism, University of SheffieldCentre for Medical Image Computing||Lungs for Living Research CentreRoyal Brompton & Harefield Hospitals, Guy?ˉs and St. Thomas?ˉ NHS Foundation Trust||Faculty of Life Sciences & MedicineUCL Respiratory, Department of MedicineMRC-University of Glasgow Centre for Virus ResearchDepartment of Immunology and InflammationCentre for Medical Informatics, The Usher InstituteSt George?ˉs University Hospitals NHS Foundation TrustThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre-RespiratoryCentre for Medical Informatics, The Usher InstituteUCL Respiratory, Department of Medicine||Royal Free London NHS Foundation TrustNewcastle Upon Tyne Hospitals NHS Foundation Trust||Population Health Sciences Institute, Newcastle UniversityThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre-RespiratoryKadoorie Centre for Critical Care Research, Nuffield Department of Clinical NeurosciencesThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre-RespiratoryThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre-RespiratoryNational Heart and Lung InstituteLeeds Teaching Hospitals NHS TrustClinical and Experimental Sciences, Faculty of Medicine||NIHR Southampton Biomedical Research CentreThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre-RespiratoryDivision of Cardiovascular Medicine, Radcliffe Department of Medicine||NIHR Oxford Biomedical Research CentreUniversity of DundeeHywel Dda University Health Board||University of Swansea, SwanseaThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre-Respiratory||Centre for Exercise and Rehabilitation Science, NIHR Leicester Biomedical Research Centre-RespiratoryNIHR Health Protection Research Unit in Emerging and Zoonotic Infections||Respiratory Medicine, Alder Hey Children?ˉs HospitalMRC Human Immunology Unit, University of Oxford||Oxford University Hospitals NHS Foundation TrustKing?ˉs College Hospital NHS Foundation Trust||King?ˉs College London British Heart Foundation CentreRoyal Infirmary of Edinburgh, NHS Lothian||Centre for Inflammation ResearchNIHR Cambridge Clinical Research Facility||NIHR Cambridge Biomedical Research CentreNational Heart and Lung InstituteOxford University Hospitals NHS Foundation Trust||NIHR Oxford Health Biomedical Research CentreDepartment of Clinical Research, London School of Hygiene & Tropical Medicine||Hospital for Tropical Diseases, University College London HospitalNIHR Leicester Biomedical Research Centre||Department of Cardiovascular Sciences, University of LeicesterUCL Respiratory, Department of MedicineCentre for Medical Informatics, The Usher InstituteNational Heart and Lung Institute||Imperial College Healthcare NHS TrustCentre for Exercise and Rehabilitation Science, NIHR Leicester Biomedical Research Centre-Respiratory||Department of Respiratory SciencesDivision of Infection, Immunity & Respiratory Medicine||Manchester University NHS Foundation TrustThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre-RespiratoryNewcastle Upon Tyne Hospitals NHS Foundation Trust||Translational and Clinical Research InstituteThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre-RespiratoryThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre-Respiratory||Department of Population Health SciencesNIHR Health Protection Research Unit in Emerging and Zoonotic Infections||Liverpool University Hospitals NHS Foundation TrustDiabetes Research Centre, University of Leicester||NIHR Leicester Biomedical Research CentreOxford University Hospitals NHS Foundation Trust||NIHR Oxford Biomedical Research CentreInstitute of Inflammation and Ageing, University of Birmingham||University Hospital Birmingham NHS Foundation TrustThe Institute for Lung Health, NIHR Leicester Biomedical Research Centre-Respiratory||Department of Population Health SciencesMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research||NIHR Birmingham Biomedical Research Centre
医学现状、医学发展医学研究方法临床医学
Kerr Steven,Briggs Andrew,Rowland-Jones Sarah L,Jolley Caroline,Poinasamy Krisnah,Raman Betty,Shikotra Aarti,Sereno Marco,Saunders Ruth M,Greening Neil J,Quint Jennifer K,Lone Nazir I,Thorpe Mathew,Heaney Liam G,Bolton Charlotte E,Diar Bakerly Nawar,Easom Nicholas,Fuld Jonathan,Hart Nick,Pfeffer Paul,Thompson AA Roger,Chalder Trudie,Greenhalf William,Heller Simon,Jacob Joseph,Man William D-C,Porter Joanna C,Scott Janet T,Thomas David C,Sheikh Aziz,Aul Raminder,Elneima Omer,Docherty Annemarie B,Hurst John R,De Soyza Anthony,Harris Victoria C,Rowland Matthew J,McAuley Hamish J C,Singapuri Amisha,Jenkins R Gisli,Beirne Paul,Jones Mark G,Brightling Christopher E,Neubauer Stefan,Chalmers James D,Lewis Keir E,Singh Sally J,Semple Malcolm G,Ho Ling-Pei,Shah Ajay M,Choudhury Gourab,Toshner Mark,Openshaw Peter JM,Geddes John R,Marks Michael,McCann Gerry P,Brown Jeremy S,Harrison Ewen M,Howard Luke S,Houchen-Wolloff Linzy,Horsley Alex,Evans Rachael A,Echevarria Carlos,Richardson Matthew,Leavy Olivia C,Wootton Dan G,Davies Melanie J,Rahman Najib M,Parekh Dhruv,Wain Louise V,Lord Janet M.Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID)[EB/OL].(2025-03-28)[2025-08-03].https://www.medrxiv.org/content/10.1101/2023.05.08.23289442.点此复制
评论