The Regulatory Evolution of the Primate Fine-Motor System
The Regulatory Evolution of the Primate Fine-Motor System
Abstract In mammals, fine motor control is essential for skilled behavior, and is subserved by specialized subdivisions of the primary motor cortex (M1) and other components of the brain’s motor circuitry. We profiled the epigenomic state of several components of the Rhesus macaque motor system, including subdivisions of M1 corresponding to hand and orofacial control. We compared this to open chromatin data from M1 in rat, mouse, and human. We found broad similarities as well as unique specializations in open chromatin regions (OCRs) between M1 subdivisions and other brain regions, as well as species- and lineage-specific differences reflecting their evolutionary histories. By distinguishing shared mammalian M1 OCRs from primate- and human-specific specializations, we highlight gene regulatory programs that could subserve the evolution of skilled motor behaviors such as speech and tool use.
Brown Ashley R.、Stauffer William R.、Pfenning Andreas R.、Wirthlin Morgan、Kaplow Irene M.、He Jing、Phan BaDoi N.、Lawler Alyssa J.
Department of Computational Biology, School of Computer Science, Carnegie Mellon University||Neuroscience Institute, Carnegie Mellon UniversityDepartment of Neurobiology, Systems Neuroscience Center, Brain Institute, Center for Neuroscience, Center for the Neural Basis of Cognition, University of PittsburghDepartment of Computational Biology, School of Computer Science, Carnegie Mellon University||Neuroscience Institute, Carnegie Mellon University||Department of Biological Sciences, Mellon College of Science, Carnegie Mellon UniversityDepartment of Computational Biology, School of Computer Science, Carnegie Mellon University||Neuroscience Institute, Carnegie Mellon UniversityDepartment of Computational Biology, School of Computer Science, Carnegie Mellon University||Neuroscience Institute, Carnegie Mellon UniversityDepartment of Neurobiology, Systems Neuroscience Center, Brain Institute, Center for Neuroscience, Center for the Neural Basis of Cognition, University of PittsburghDepartment of Computational Biology, School of Computer Science, Carnegie Mellon UniversityNeuroscience Institute, Carnegie Mellon University||Department of Biological Sciences, Mellon College of Science, Carnegie Mellon University
分子生物学
Brown Ashley R.,Stauffer William R.,Pfenning Andreas R.,Wirthlin Morgan,Kaplow Irene M.,He Jing,Phan BaDoi N.,Lawler Alyssa J..The Regulatory Evolution of the Primate Fine-Motor System[EB/OL].(2025-03-28)[2025-05-07].https://www.biorxiv.org/content/10.1101/2020.10.27.356733.点此复制
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