Altered cortical processing of sensory input in Huntington disease mouse models
Altered cortical processing of sensory input in Huntington disease mouse models
Abstract Huntington disease (HD), a hereditary neurodegenerative disorder, manifests as progressively impaired movement and cognition. Although early abnormalities of neuronal activity in striatum are well established in HD models, there are fewer in vivo studies of the cortex. Here, we record local field potentials (LFPs) in YAC128 HD model mice versus wild-type mice. In multiple cortical areas, limb sensory stimulation evokes a greater change in LFP power in YAC128 mice. Mesoscopic imaging using voltage-sensitive dyes reveal more extensive spread of evoked sensory signals across the cortical surface in YAC128 mice. YAC128 layer 2/3 sensory cortical neurons ex vivo show increased excitatory events, which could contribute to enhanced sensory responses in vivo. Cortical LFP responses to limb stimulation, visual and auditory input are also significantly increased in zQ175 HD mice. Results presented here extend knowledge of HD beyond ex vivo studies of individual neurons to the intact cortical network.
Xiao Dongsheng、Chan Allan W.、Murphy Timothy H.、Sepers Marja D.、Mackay James P.、Ramandi Daniel、Mohajerani Majid H.、Raymond Lynn A.、Smith-Dijak Amy I.、Koch Ellen
Department of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British ColumbiaDepartment of Psychiatry, University of AlbertaDepartment of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British ColumbiaDepartment of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British ColumbiaDepartment of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British ColumbiaDepartment of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British ColumbiaCanadian Center for Behavioural Neuroscience, University of LethbridgeDepartment of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British ColumbiaDepartment of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British ColumbiaDepartment of Psychiatry and Djavad Mowafaghian Centre for Brain Health, University of British Columbia
神经病学、精神病学基础医学生物科学研究方法、生物科学研究技术
Xiao Dongsheng,Chan Allan W.,Murphy Timothy H.,Sepers Marja D.,Mackay James P.,Ramandi Daniel,Mohajerani Majid H.,Raymond Lynn A.,Smith-Dijak Amy I.,Koch Ellen.Altered cortical processing of sensory input in Huntington disease mouse models[EB/OL].(2025-03-28)[2025-05-03].https://www.biorxiv.org/content/10.1101/2021.07.18.452688.点此复制
评论