Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

作者：Wang Ya-Xing、Kim Bong-Jo、Suzuki Ken、Sheu Wayne HH、Roden Michael、Ferrer Jorge、Bharadwaj Dwaipayan、Kooperberg Charles、Psaty Bruce M、Guo Xiuqing、Zeggini Eleftheria、Sander Maike、Koh Woon-Puay、Froguel Philippe、Linneberg Allan、Luk Andrea O、Yusuf Salim、Huang Mengna、Kamatani Yoichiro、Ikram Mohammad Arfan、Islam Md. Tariqul、J?rgensen Marit E、Kasturiratne Anuradhani、Katsuya Tomohiro、Kawaguchi Takahisa、Keaton Jacob M、Kohara Katsuhiko、Kriebel Jennifer、Kronenberg Florian、Kuusisto Johanna、Lange Leslie A、Li Liming、Louie Tin、Luo Xi、Meitinger Thomas、van Klinken Jan B、Varma Rohit、Whitsel Eric A、Mamakou Vasiliki、Morris Andrew D、Yamamoto Ken、Yengo Lo?c、Yoon Kyungheon、Yu Canqing、Zhang Liang、Zheng Wei、FinnGen、Ipp Eli、Wilson James G、Ma Ronald CW、Collins Francis S、Cho Yoon Shin、Peyser Patricia A、Ingelsson Erik、Becker Diane M、Matsuda Fumihiko、Liu Yongmei、Nadler Jerry L、Nalls Michael A、So Wing Yee、Stilp Adrienne M、Takahashi Atsushi、Taylor Kent D、Tusie-Luna Teresa、Udler Miriam S、Pirie Fraser J、Prasad Gauri、Rohde Rebecca、Giedraitis Vilmantas、Gonz¨￠lez-Villalpando Clicerio、Han Sohee、Hattersley Andrew T、Howard Annie-Green、Sandow Kevin、Sch?nherr Sebastian、Shahriar Mohammad、Shi Jinxiu、Engert James C、Taliun Daniel、Robertson Neil R、Chiou Joshua、Miguel-Escalada Irene、Bragg Fiona、Preuss Michael H、Lamri Amel、Nakatochi Masahiro、Scott Robert A、Lee Jung-Jin、Huerta-Chagoya Alicia、Chai Jin-Fang、Parra Esteban J、Trompet Stella、Chen Wei-Min、Noordam Raymond、Maruthur Nisa M、Tan Jingyi、Adair Linda S、Bian Zheng、Brandslund Ivan、Brody Jennifer A、Brummett Chad M、Chang Li-Ching、Chee Miao-Li、Chen Ji、Chen Shyh-Huei、Mahajan Anubha、Spracklen Cassandra N、Petty Lauren E、Yu Grace Z、Mercader Josep M、Chen Zhengming、Chuang Lee-Ming、Cushman Mary、Das Swapan K、Du Shufa、Emery Leslie S、Fischer Krista、Ford Ian、Fuchsberger Christian、Kim Duk-Hwan、Lin Kuang、Rich Stephen S、Thorsteinsdottir Unnur、Briotta Parolo Pietro della、McCarthy Mark I、Rotter Jerome I、McKean-Cowdin Roberta、Maeda Shiro、Mohlke Karen L、Bowden Donald W、Sim Xueling、Wareham Nicholas J、Lee Juyoung、Stefansson Kari、Gaulton Kyle J、Dupuis Josee、Morris Andrew P、Kato Norihiro、Palmer Colin NA、Haiman Christopher A、Florez Jose C、Bielak Lawrence F、Tabara Yasuharu、Kals Mart、Sofer Tamar、Wuttke Matthias、Goodarzi Mark O、Gorkin David、Gross Myron、Guo Yu、Hanis Craig L、Chandak Giriraj R、Kim Young Jin、Chen Chien-Hsiun、Horikoshi Momoko、Saleheen Danish、Gieger Christian、Pereira Mark A、Tai E-Shyong、Khor Chiea-Chuen、Frayling Timothy M、Kabagambe Edmond、Ingelsson Martin、Evans Michele K、Bottinger Erwin P、Nousome Darryl、An Ping、Adeyemo Adebowale、Lecoeur C¨|cile、Rasmussen-Torvik Laura J、Choi Hyeok Sun、Lv Jun、Huang Wei、North Kari E、Pan Ian、Graff Mariaelisa、Ahmad Meraj、Doumatey Ayo P、Loos Ruth JF、Chen Guanjie、Yao Jie、Wickremasinghe Ananda R、Nano Jana、Kitajima Hidetoshi、Hai Yang、Cheng Ching-Yu、Locke Adam E、Hayes M Geoffrey、Hwu Chii-Min、J?rgensen Torben、Chen Yuan-Tsong、Jasmine Farzana、Abaitua Fernando、Reiner Alexander P、Metspalu Andres、Thorleifsson Gudmar、Sarnowski Chloe、Kardia Sharon LR、Sabanayagam Charumathi、Shriner Daniel、Tong Lin、van Dam Rob M、Ng Maggie CY、Patel Sanjay R、Jukema J Wouter、Luan Jian?ˉan、Sattar Naveed、Gonz¨￠lez-Villalpando Maria Elena、Takeuchi Fumihiko、Schurmann Claudia、Pedersen Oluf、Anand Sonia S、Moon Sanghoon、Rayner Nigel W、Kandeel Fouad R、Hsueh Willa、Millwood Iona Y、Hung Yi-Jen、Lindgren Cecilia M、Lee Myung-Shik、Chambers John C、Rotimi Charles N、Dehghan Abbas、Sale Mich¨¨le M、Jensen Richard A、Canouil Micka?l、Langenberg Claudia、Isono Masato、Ahsan Habibul、Chan Juliana CN、Jonas Jost B、Abecasis Goncalo、Yamauchi Toshimasa、L?ll Kristi、Motala Ayesha A、Schmidt Ellen M、Torres Jason M、Liu Simin、Yokota Mitsuhiro、Zonderman Alan B、Liu Jianjun、Boehnke Michael、Gordon-Larsen Penny、Nadkarni Girish N.、Raffield Laura M、Long Jirong、Pankow James S、Eckardt Kai-Uwe、Tomlinson Brian、Wacher-Rodarte Niels、Jiang Guozhi、Freedman Barry I、Dedoussis George、Ntalla Ioanna、Orozco Lorena、Shin Dong Mun、Buchanan Thomas A、R¨1eger Sina、Herder Christian、Gloyn Anna L、Par¨| Guillaume、Aguilar-Salinas Carlos A、Genter Pauline、Evans Daniel S、Xiang Anny H、Meigs James B、Witte Daniel R、Zhang Weihua、Strauch Konstantin、Lim Victor JY、Tsai Fuu-Jen、Nayak Uma、Shu Xiao-Ou、Ichihara Sahoko、Yuan Jian-Min、Roll Katheryn、Mani K Radha、Kho Abel N、Okada Yukinori、Loh Marie、Groop Leif、Steinthorsdottir Valgerdur、Joo Yoonjung Yoonie、Bork-Jensen Jette、Bertoni Alain、Duan Qing、Grarup Niels、K?ttgen Anna、Yajnik Chittaranjan S、Akiyama Masato、Walters Robin G、Leong Aaron、Sun Meng、Vujkovic Marijana、Yanek Lisa R、Li Yun、Cade Brian E、Peters Annette、Tam Claudia HT、Fornage Myriam、Liu Ching-Ti、Below Jennifer E、Prins Bram Peter、Cook James P、de Silva H. Janaka、Laakso Markku、Nicolas Aude、Porneala Bianca、Wong Tien-Yin、Franco Oscar H、Lyssenko Valeriya、Grallert Harald、Hackinger Sophie、Kaur Varinderpal、Speidel Leo、Tuomilehto Jaakko、Jang Hye-Mi、Province Michael A、Hwang Mi Yeong、Dimitrov Latchezar、Igase Michiya、Wheeler Ellie、Preissl Sebastian、Mook-Kanamori Dennis O、Raffel Leslie J、Myers Simon R、Smith Jennifer A、Stan?¨￠kov¨￠ Alena、Thorand Barbara、Gerstein Hertzel C、van Dijk Konstantin Willems、Kadowaki Takashi、Kooner Jaspal S、Cruz Miguel、Wu Jer-Yuarn、Lee Nanette R、Kwak Soo-Heon、Valladares-Salgado Adan、Tajuddin Salman、M?gi Reedik、Chen Yii-Der Ida、Li-Gao Ruifang、Lind Lars、Kibriya Muhammad G、Redline Susan、Hansen Torben、Ligthart Symen、Floyd James S、Park Kyong-Soo

作者单位：Beijing Institute of Ophthalmology, Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical UniversityDivision of Genome Research, Center for Genome Science, National Institute of HealthLaboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Centre for Integrative Medical Sciences||Laboratory for Statistical and Translational Genetics, RIKEN Centre for Integrative Medical Sciences||Department of Statistical Genetics, Osaka University Graduate School of Medicine||Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of TokyoSchool of Medicine, National Defense Medical Center||School of Medicine, National Yang-Ming University||Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General HospitalGerman Center for Diabetes Research (DZD)||Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University D¨1sseldorf||Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University D¨1sseldorfRegulatory Genomics and Diabetes, Centre for Genomic Regulation, The Barcelona Institute of Science and Technology||Centro de Investigaci¨?n Biom¨|dica en Red Diabetes y Enfermedades Metab¨?licas asociadas (CIBERDEM)||Section of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College LondonAcademy of Scientific and Innovative Research, CSIR-Institute of Genomics and Integrative Biology||Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru UniversityFred Hutchinson Cancer Research CenterCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington||Kaiser Permanente Washington Research InstituteThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical CenterDepartment of Human Genetics, Wellcome Sanger Institute||Institute of Translational Genomics, Helmholtz Zentrum M¨1nchen, German Research Center for Environmental Health||TUM School of Medicine, Technical University of Munich and Klinikum Rechts der IsarDepartment of Pediatrics, Pediatric Diabetes Research Center, University of California San Diego||Institute for Genomic Medicine, University of California San Diego||Department of Cellular and Molecular Medicine, University of California San DiegoSaw Swee Hock School of Public Health, National University of Singapore and National University Health System||Health Services and Systems Research, Duke-NUS Medical SchoolCNRS-UMR8199, Lille Pasteur Institute, Lille University||Department of Genomics of Common Disease, School of Public Health, Imperial College LondonCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital||Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of CopenhagenDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong||Chinese University of Hong Kong- Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, The Chinese University of Hong KongDepartment of Medicine, McMaster University||Population Health Research Institute, Hamilton Health Sciences and McMaster University||Department of Health Research Methods, Evidence, and Impact, McMaster UniversityDepartment of Epidemiology, Brown University School of Public Health||Center for Global Cardiometabolic Health, Brown UniversityLaboratory for Statistical and Translational Genetics, RIKEN Centre for Integrative Medical Sciences||Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of TokyoDepartment of Epidemiology, Erasmus University Medical CenterUniversity of Chicago Research BangladeshSteno Diabetes Center Copenhagen||National Institute of Public Health, Southern Denmark UniversityDepartment of Public Health, Faculty of Medicine, University of KelaniyaDepartment of Clinical Gene Therapy, Osaka University Graduate School of Medicine||Department of Geriatric and General Medicine, Graduate School of Medicine, Osaka UniversityCenter for Genomic Medicine, Kyoto University Graduate School of MedicineCenter for Genomics and Personalized Medicine Research, Wake Forest School of Medicine||Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical CenterDepartment of Regional Resource Management, Ehime University Faculty of Collaborative Regional InnovationGerman Center for Diabetes Research (DZD)||Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental HealthInstitute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of InnsbruckInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University HospitalDepartment of Medicine, University of Colorado Denver, Anschutz Medical CampusDepartments of Epidemiology and Biostatistics, Peking University Health Science Centre, Peking UniversityDepartment of Biostatistics, University of WashingtonDepartment of Biostatistics and Data Science, University of Texas Health Science Center at HoustonInstitute of Human Genetics, Helmholtz Zentrum M¨1nchen, German Research Center for Environmental Health||Institute of Human Genetics, Technical University of Munich||German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart AllianceEinthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center||Department of Human Genetics, Leiden University Medical Center||Department of Clinical Chemistry, Laboratory of Genetic Metabolic Disease, Amsterdam University Medical CenterOphthalmology, Southern California Eye Institute, CHA Hollywood Presbyterian HospitalDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill||Department of Medicine, School of Medicine, University of North Carolina at Chapel HillDromokaiteio Psychiatric Hospital, National and Kapodistrian University of AthensThe Usher Institute to the Population Health Sciences and Informatics, University of EdinburghDepartment of Medical Biochemistry, Kurume University School of MedicineCNRS-UMR8199, Lille Pasteur Institute, Lille University||Institute for Molecular Bioscience, University of QueenslandDivision of Genome Research, Center for Genome Science, National Institute of HealthDepartments of Epidemiology and Biostatistics, Peking University Health Science Centre, Peking UniversitySingapore Eye Research Institute, Singapore National Eye CentreDivision of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical CenterDepartment of Medicine, Division of Endocrinology and Metabolism, Lundquist Research Institute at Harbor-UCLA Medical CenterDepartment of Physiology and Biophysics, University of Mississippi Medical CenterDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong||Chinese University of Hong Kong- Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, The Chinese University of Hong Kong||Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong||Li Ka Shing Institute of Health Sciences, The Chinese University of Hong KongGenome Technology Branch, National Human Genome Research Institute, National Institutes of HealthDepartment of Biomedical Science, Hallym UniversityDepartment of Epidemiology, School of Public Health, University of MichiganDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine||Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala UniversityDepartment of Medicine, Johns Hopkins University School of MedicineCenter for Genomic Medicine, Kyoto University Graduate School of MedicineDepartment of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine||Department of Medicine, Division of Cardiology, Duke University School of MedicineDepartment of Medicine and Pharmacology, New York Medical CollegeLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health||Data Tecnica International LLC||Kelly ServicesDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong||Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong KongDepartment of Biostatistics, University of WashingtonLaboratory for Statistical and Translational Genetics, RIKEN Centre for Integrative Medical Sciences||Department of Genomic Medicine, National Cerebral and Cardiovascular CenterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical CenterUnidad de Biolog¨aa Molecular y Medicina Gen¨?mica, Instituto Nacional de Ciencias M¨|dicas y Nutrici¨?n Salvador Zubir¨￠n||Departamento de Medicina Gen¨?mica y Toxiolog¨aa Ambiental, Instituto de Investigaciones Biom¨|dicasPrograms in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT||Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital||Department of Medicine, Harvard Medical SchoolDepartment of Diabetes and Endocrinology, Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-NatalAcademy of Scientific and Innovative Research, CSIR-Institute of Genomics and Integrative Biology||Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative BiologyDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel HillDepartment of Public Health and Caring Sciences, Uppsala UniversityCentro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud PublicaDivision of Genome Research, Center for Genome Science, National Institute of HealthUniversity of Exeter Medical School, University of ExeterDepartment of Biostatistics, Carolina Population Center, Gillings School of Global Public Health, University of North Carolina at Chapel HillThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical CenterInstitute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of InnsbruckBiological Sciences Division, Public Health Sciences, The University of ChicagoDepartment of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at ShanghaiDepartment of Medicine, McGill University||Department of Human Genetics, McGill UniversityDepartment of Biostatistics and Center for Statistical Genetics, University of MichiganOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford||Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of OxfordBiomedical Sciences Graduate Studies Program, University of California San DiegoRegulatory Genomics and Diabetes, Centre for Genomic Regulation, The Barcelona Institute of Science and Technology||Centro de Investigaci¨?n Biom¨|dica en Red Diabetes y Enfermedades Metab¨?licas asociadas (CIBERDEM)Nuffield Department of Population Health, University of OxfordThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount SinaiDepartment of Medicine, McMaster University||Population Health Research Institute, Hamilton Health Sciences and McMaster UniversityPublic Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of MedicineMRC Epidemiology Unit, Institute of Metabolic Science, University of CambridgeDivision of Translational Medicine and Human Genetics, University of PennsylvaniaConsejo Nacional de Ciencia y Tecnolog¨aa (CONACYT), Instituto Nacional de Ciencias M¨|dicas y Nutrici¨?n Salvador Zubir¨￠nSaw Swee Hock School of Public Health, National University of Singapore and National University Health SystemDepartment of Anthropology, University of Toronto at MississsaugaDepartment of Cardiology, Leiden University Medical Center||Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical CenterDepartment of Public Health Sciences and Center for Public Health Genomics, University of Virginia School of MedicineSection of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical CenterDepartment of Epidemiology, Johns Hopkins University||Department of Medicine, Johns Hopkins University School of MedicineThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical CenterDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel HillChinese Academy of Medical SciencesInstitute of Regional Health Research, University of Southern Denmark||Department of Clinical Biochemistry, Vejle HospitalCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of WashingtonDepartment of Anesthesiology, University of Michigan Medical SchoolInstitute of Biomedical Sciences, Academia SinicaSingapore Eye Research Institute, Singapore National Eye CentreWellcome Sanger InstituteDepartment of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest University Health SciencesOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford||Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford||Genentech, 1 DNA Way, South San FranciscoDepartment of Genetics, University of North Carolina at Chapel Hill||Department of Epidemiology and Biostatistics, University of Massachusetts-AmherstVanderbilt Genetics Institute, Vanderbilt University Medical CenterOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford||Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of OxfordPrograms in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT||Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital||Harvard Medical SchoolNuffield Department of Population Health, University of Oxford||Medical Research Council Population Health Research Unit, University of OxfordDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital||Institute of Preventive Medicine, School of Public Health, National Taiwan UniversityDepartment of Medicine, University of VermontSection on Endocrinology and Metabolism, Department of Internal Medicine, Wake Forest School of MedicineDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel HillDepartment of Biostatistics, University of WashingtonEstonian Genome Center, Institute of Genomics, University of TartuRobertson Centre for Biostatistics, University of GlasgowDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan||Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of L¨1beckDepartment of Molecular Cell Biology, Sungkyunkwan University School of MedicineNuffield Department of Population Health, University of OxfordCenter for Public Health Genomics, University of Virginia School of MedicinedeCODE Genetics, Amgen inc.||Faculty of Medicine, University of ReykjavikFinnish Institute for Molecular Medicine (FIMM), University of HelsinkiOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford||Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford||Oxford NIHR Biomedical Research Centre, Churchill Hosptial, Oxford University Hospitals NHS Foundation Trust||Genentech, 1 DNA Way, South San FranciscoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical CenterDepartment of Preventive Medicine, Keck School of Medicine of USCLaboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Centre for Integrative Medical Sciences||Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus||Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus HospitalDepartment of Genetics, University of North Carolina at Chapel HillCenter for Genomics and Personalized Medicine Research, Wake Forest School of Medicine||Department of Biochemistry, Wake Forest School of Medicine||Center for Diabetes Research, Wake Forest School of MedicineSaw Swee Hock School of Public Health, National University of Singapore and National University Health SystemMRC Epidemiology Unit, Institute of Metabolic Science, University of CambridgeDivision of Genome Research, Center for Genome Science, National Institute of HealthdeCODE Genetics, Amgen inc.||Faculty of Medicine, University of ReykjavikDepartment of Pediatrics, Pediatric Diabetes Research Center, University of California San Diego||Institute for Genomic Medicine, University of California San DiegoDepartment of Biostatistics, Boston University School of Public HealthWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford||Department of Biostatistics, University of Liverpool||Estonian Genome Center, Institute of Genomics, University of Tartu||Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of ManchesterDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and MedicinePat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, University of DundeeDepartment of Preventive Medicine, Keck School of Medicine of USCPrograms in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT||Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital||Department of Medicine, Harvard Medical SchoolDepartment of Epidemiology, School of Public Health, University of MichiganCenter for Genomic Medicine, Kyoto University Graduate School of MedicineEstonian Genome Center, Institute of Genomics, University of TartuDepartment of Biostatistics, Harvard University||Division of Sleep and Circadian Disorders, Brigham and Women?ˉs Hospital||Department of Medicine, Harvard UniversityInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology, and Medical Bioinformatics, Faculty of Medicine and Medical Center, University of FreiburgDepartment of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical CenterCentre for Epigenomics, University of California San DiegoDepartment of Laboratory Medicine and Pathology, University of MinnesotaChinese Academy of Medical SciencesHuman Genetics Center, University of Texas Health Science Center at HoustonGenomic Research on Complex Diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB)Division of Genome Research, Center for Genome Science, National Institute of HealthInstitute of Biomedical Sciences, Academia SinicaLaboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Centre for Integrative Medical SciencesDivision of Translational Medicine and Human Genetics, University of Pennsylvania||Department of Biostatistics and Epidemiology, University of Pennsylvania||Center for Non-Communicable DiseasesGerman Center for Diabetes Research (DZD)||Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental HealthDivision of Epidemiology and Community Health, School of Public Health, University of MinnesotaSaw Swee Hock School of Public Health, National University of Singapore and National University Health System||Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System||Duke-NUS Medical SchoolGenome Institute of Singapore, Agency for Science, Technology and Research||Department of Biochemistry, National University of SingaporeGenetics of Complex Traits, University of Exeter Medical School, University of ExeterDivision of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical CenterDepartment of Public Health and Caring Sciences, Uppsala UniversityLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of HealthThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai||Digital Health Center, Digital Engineering Faculty of Hasso Plattner Institue and University Potsdam||Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount SinaiDepartment of Preventive Medicine, Keck School of Medicine of USCDivision of Statistical Genomics, Washington University School of MedicineCenter for Research on Genomics and Global Health, National Human Genome Institute, National Institutes of HealthCNRS-UMR8199, Lille Pasteur Institute, Lille UniversityDepartment of Preventive Medicine, Northwestern University Feinberg School of MedicineDepartment of Biomedical Science, Hallym UniversityDepartments of Epidemiology and Biostatistics, Peking University Health Science Centre, Peking UniversityDepartment of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at ShanghaiDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel HillDepartment of Epidemiology, Brown University School of Public HealthDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel HillGenomic Research on Complex Diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB)Center for Research on Genomics and Global Health, National Human Genome Institute, National Institutes of HealthThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai||The Mindich Child Health and Development Institute, Ichan School of Medicine at Mount SinaiCenter for Research on Genomics and Global Health, National Human Genome Institute, National Institutes of HealthThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical CenterDepartment of Public Health, Faculty of Medicine, University of KelaniyaDepartment of Epidemiology, Erasmus University Medical CenterWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford||The Advanced Research Center for Innovations in Next- Generation Medicine (INGEM), Tohoku University||Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University||Cancer Center, Tohoku University Hospital, Tohoku UniversityThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical CenterSingapore Eye Research Institute, Singapore National Eye Centre||Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School||Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health SystemMcDonnell Genome Institute, Washington University School of Medicine||Department of Medicine, Division of Genomics and Bioinformatics, Washington University School of MedicineDivision of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine||Center for Genetic Medicine, Northwestern University Feinberg School of Medicine||Department of Anthropology, Northwestern UniversitySection of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital||School of Medicine, National Yang-Ming UniversityCenter for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital||Faculty of Health and Medical Sciences, University of Copenhagen||Faculty of Medicine, Aalborg UniversityInstitute of Biomedical Sciences, Academia SinicaBiological Sciences Division, Public Health Sciences, The University of ChicagoWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of OxfordFred Hutchinson Cancer Research CenterEstonian Genome Center, Institute of Genomics, University of TartudeCODE Genetics, Amgen inc.Department of Biostatistics, Boston University School of Public HealthDepartment of Epidemiology, School of Public Health, University of MichiganSingapore Eye Research Institute, Singapore National Eye Centre||Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School||Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health SystemCenter for Research on Genomics and Global Health, National Human Genome Institute, National Institutes of HealthBiological Sciences Division, Public Health Sciences, The University of ChicagoSaw Swee Hock School of Public Health, National University of Singapore and National University Health System||Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System||Department of Nutrition, Harvard T.H. Chan School of Public HealthVanderbilt Genetics Institute, Vanderbilt University Medical Center||Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine||Department of Biochemistry, Wake Forest School of Medicine||Division of Genetic Medicine, Vanderbilt University Medical CenterDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of PittsburghDepartment of Cardiology, Leiden University Medical Center||Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical CenterMRC Epidemiology Unit, Institute of Metabolic Science, University of CambridgeInstitute of Cardiovascular and Medical Sciences, University of GlasgowCentro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud PublicaDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and MedicineThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai||Digital Health Center, Digital Engineering Faculty of Hasso Plattner Institue and University Potsdam||Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount SinaiThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of CopenhagenDepartment of Medicine, McMaster University||Population Health Research Institute, Hamilton Health Sciences and McMaster University||Department of Health Research Methods, Evidence, and Impact, McMaster UniversityDivision of Genome Research, Center for Genome Science, National Institute of HealthOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford||Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford||Department of Human Genetics, Wellcome Sanger Institute||Institute of Translational Genomics, Helmholtz Zentrum M¨1nchen, German Research Center for Environmental HealthDepartment of Clinical Diabetes, Endocrinology & Metabolism, Department of Translational Research and Cellular TherapeuticsDepartment of Internal Medicine, Diabetes and Metabolism Research Center, Ohio State University Wexner Medical CenterNuffield Department of Population Health, University of Oxford||Medical Research Council Population Health Research Unit, University of OxfordDivision of Endocrine and Metabolism, Tri-Service General Hospital Songshan Branch||School of Medicine, National Defense Medical CenterWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford||Program in Medical & Population Genetics, Broad Institute||Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of OxfordSeverance Biomedical Science Institute and Department of Internal Medicine, Yonsei University College of Medicine||Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Epidemiology and Biostatistics, Imperial College London||Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust||Lee Kong Chian School of Medicine, Nanyang Technological University||MRC-PHE Centre for Environment and Health, Imperial College London||Imperial College Healthcare NHS Trust, Imperial College LondonCenter for Research on Genomics and Global Health, National Human Genome Institute, National Institutes of HealthDepartment of Epidemiology and Biostatistics, Imperial College London||Department of Epidemiology, Erasmus University Medical Center||MRC-PHE Centre for Environment and Health, Imperial College LondonDepartment of Public Health Sciences and Center for Public Health Genomics, University of Virginia School of MedicineCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of WashingtonCNRS-UMR8199, Lille Pasteur Institute, Lille UniversityMRC Epidemiology Unit, Institute of Metabolic Science, University of CambridgeDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and MedicineBiological Sciences Division, Public Health Sciences, The University of ChicagoDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong||Chinese University of Hong Kong- Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, The Chinese University of Hong Kong||Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong||Li Ka Shing Institute of Health Sciences, The Chinese University of Hong KongDepartment of Ophthalmology, Medical Faculty Mannheim of the University of HeidelbergDepartment of Biostatistics and Center for Statistical Genetics, University of MichiganDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of TokyoEstonian Genome Center, Institute of Genomics, University of Tartu||Institute of Mathematics and Statistics, University of TartuDepartment of Diabetes and Endocrinology, Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-NatalDepartment of Biostatistics and Center for Statistical Genetics, University of MichiganWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of OxfordDepartment of Epidemiology, Brown University School of Public Health||Center for Global Cardiometabolic Health, Brown University||Department of Medicine, Brown University Alpert School of MedicineKurume University School of MedicineLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of HealthGenome Institute of Singapore, Agency for Science, Technology and Research||Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health SystemDepartment of Biostatistics and Center for Statistical Genetics, University of MichiganDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel HillThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai||Digital Health Center, Digital Engineering Faculty of Hasso Plattner Institue and University PotsdamDepartment of Genetics, University of North Carolina at Chapel HillDivision of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical CenterDivision of Epidemiology and Community Health, School of Public Health, University of MinnesotaDepartment of Nephrology and Medical Intensive Care Medicine, Charit¨| Universit?tsmedizin Berlin||Department of Nephrology and Hypertension, Friedrich-Alexander-Universit?t Erlangen- N¨1rnbergDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong||Faculty of Medicine, Macau University of Science and TechnologyUnidad de Investigaci¨?n M¨|dica en Epidemiologia Clinica, Hospital de Especialidades, Centro Medico Nacional Siglo XXIDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong||Chinese University of Hong Kong- Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, The Chinese University of Hong KongDepartment of Internal Medicine, Wake Forest School of MedicineDepartment of Nutrition and Dietetics, Harokopio University of AthensWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonInstituto Nacional de Medicina Gen¨?micaDivision of Genome Research, Center for Genome Science, National Institute of HealthDepartment of Medicine, Division of Endocrinology and Diabetes, Keck School of Medicine of USCFinnish Institute for Molecular Medicine (FIMM), University of HelsinkiGerman Center for Diabetes Research (DZD)||Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University D¨1sseldorf||Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University D¨1sseldorfOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford||Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford||Oxford NIHR Biomedical Research Centre, Churchill Hosptial, Oxford University Hospitals NHS Foundation Trust||Division of Endocrinology, Department of Pediatrics, Stanford School of Medicine, Stanford UniversityPopulation Health Research Institute, Hamilton Health Sciences and McMaster University||Department of Pathology and Molecular Medicine, McMaster UniversityUnidad de Investigaci¨?n en Enfermedades Metab¨?licas and Departamento de Endocrinolog¨aa y Metabolismo, Instituto Nacional de Ciencias M¨|dicas y Nutrici¨?n Salvador Zubir¨￠nDepartment of Medicine, Division of Endocrinology and Metabolism, Lundquist Research Institute at Harbor-UCLA Medical CenterCalifornia Pacific Medical Center Research InstituteDepartment of Research and Evaluation, Division of Biostatistics Research, Kaiser Permanente of Southern CaliforniaPrograms in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT||Department of Medicine, Harvard Medical School||Division of General Internal Medicine, Massachusetts General HospitalDepartment of Public Health, Aarhus University||Danish Diabetes AcademyDepartment of Epidemiology and Biostatistics, Imperial College London||Department of Cardiology, Ealing Hospital, London North West Healthcare NHS TrustInstitute of Genetic Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health||Institute for Medical Informatics Biometry and Epidemiology, Ludwig-Maximilians UniversitySaw Swee Hock School of Public Health, National University of Singapore and National University Health SystemDepartment of Medical Genetics and Medical Research, China Medical University HospitalDepartment of Public Health Sciences and Center for Public Health Genomics, University of Virginia School of MedicineDivision of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical CenterDepartment of Environmental and Preventive Medicine, Jichi Medical University School of MedicineDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh||Department of Epidemiology, Graduate School of Public Health, University of PittsburghThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical CenterGenomic Research on Complex Diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB)Division of General Internal Medicine and Geriatrics, Department of Medicine, Northwestern University Feinberg School of Medicine||Center for Health Information Partnerships, Institute for Public Health and Medicine, Northwestern University Feinberg School of MedicineDepartment of Statistical Genetics, Osaka University Graduate School of Medicine||Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka UniversityDepartment of Epidemiology and Biostatistics, Imperial College London||Lee Kong Chian School of Medicine, Nanyang Technological University||Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR) and National University of Singapore (NUS)Finnish Institute for Molecular Medicine (FIMM), University of Helsinki||Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes CentredeCODE Genetics, Amgen inc.Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine||Department of Health and Biomedical Informatics, Northwestern University Feinberg School of MedicineThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of CopenhagenDepartment of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of MedicineDepartment of Genetics, University of North Carolina at Chapel HillThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of CopenhagenInstitute of Genetic Epidemiology, Department of Biometry, Epidemiology, and Medical Bioinformatics, Faculty of Medicine and Medical Center, University of FreiburgDiabetology Research Centre, King Edward Memorial Hospital and Research CentreLaboratory for Statistical and Translational Genetics, RIKEN Centre for Integrative Medical Sciences||Department of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu UniversityNuffield Department of Population Health, University of Oxford||Medical Research Council Population Health Research Unit, University of OxfordDepartment of Medicine, Harvard Medical School||Division of General Internal Medicine, Massachusetts General HospitalWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of OxfordDepartment of Medicine, University of Pennsylvania Perelman School of MedicineDepartment of Medicine, Johns Hopkins University School of MedicineDepartment of Genetics, University of North Carolina at Chapel HillDivision of Sleep and Circadian Disorders, Brigham and Women?ˉs Hospital||Harvard Medical SchoolGerman Center for Diabetes Research (DZD)||Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health||German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart AllianceDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong||Chinese University of Hong Kong- Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, The Chinese University of Hong KongInstitute of Molecular Medicine, University of Texas Health Science Center at HoustonDepartment of Biostatistics, Boston University School of Public HealthVanderbilt Genetics Institute, Vanderbilt University Medical CenterDepartment of Human Genetics, Wellcome Sanger InstituteDepartment of Biostatistics, University of LiverpoolDepartment of Medicine, Faculty of Medicine, University of KelaniyaInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University HospitalLaboratory of Neurogenetics, National Institute on Aging, National Institutes of HealthDivision of General Internal Medicine, Massachusetts General HospitalSingapore Eye Research Institute, Singapore National Eye Centre||Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School||Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health SystemDepartment of Epidemiology, Erasmus University Medical CenterDepartment of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre||Department of Clinical Science, KG Jebsen Center for Diabetes Research, University of BergenGerman Center for Diabetes Research (DZD)||Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health||Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum M¨1nchen, Ludwig-Maximilians University||Clinical Cooperation Group Nutrigenomics and Type 2 Diabetes, Helmholtz Zentrum M¨1nchen, Technical University of MunichDepartment of Human Genetics, Wellcome Sanger InstituteDiabetes Unit and Center for Genomic Medicine, Massachusetts General HospitalDepartment of Statistics, University of OxfordDepartment of Health, National Institute for Health and Welfare||National School of Public Health||Department of Neuroscience and Preventive Medicine, Danube-University Krems||Diabetes Research Group, King Abdulaziz UniversityDivision of Genome Research, Center for Genome Science, National Institute of HealthDivision of Statistical Genomics, Washington University School of MedicineDivision of Genome Research, Center for Genome Science, National Institute of HealthCenter for Genomics and Personalized Medicine Research, Wake Forest School of MedicineDepartment of Anti-aging Medicine, Ehime University Graduate School of MedicineMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge||Wellcome Sanger InstituteCentre for Epigenomics, University of California San DiegoDepartment of Clinical Epidemiology, Leiden University Medical CenterDepartment of Pediatrics, Division of Genetic and Genomic Medicine, UCI Irvine School of MedicineWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford||Department of Statistics, University of OxfordDepartment of Epidemiology, School of Public Health, University of Michigan||Survey Research Center, Institute for Social Research, University of MichiganInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University HospitalGerman Center for Diabetes Research (DZD)||Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental HealthDepartment of Medicine, McMaster University||Population Health Research Institute, Hamilton Health Sciences and McMaster University||Department of Health Research Methods, Evidence, and Impact, McMaster UniversityEinthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center||Department of Human Genetics, Leiden University Medical Center||Department of Internal Medicine, Division of Endocrinology, Leiden University Medical CenterDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of TokyoDepartment of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust||MRC-PHE Centre for Environment and Health, Imperial College London||Imperial College Healthcare NHS Trust, Imperial College London||National Heart and Lung Institute, Imperial College LondonUnidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXIInstitute of Biomedical Sciences, Academia SinicaDepartment of Anthropology, Sociology and History, University of San CarlosDepartment of Internal Medicine, Seoul National University HospitalUnidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXILaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of HealthEstonian Genome Center, Institute of Genomics, University of TartuThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical CenterDepartment of Clinical Epidemiology, Leiden University Medical CenterDepartment of Medical Sciences, Uppsala UniversityBiological Sciences Division, Public Health Sciences, The University of ChicagoDivision of Sleep and Circadian Disorders, Brigham and Women?ˉs Hospital||Harvard Medical School||Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical CenterThe Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of CopenhagenDepartment of Epidemiology, Erasmus University Medical CenterCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of WashingtonDepartment of Internal Medicine, Seoul National University Hospital||Department of Internal Medicine, Seoul National University College of Medicine||Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University

DOI：10.1101/2020.09.22.20198937

学科分类：医学研究方法基础医学遗传学

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