Profiling of small non-coding RNAs across cellular and biofluid compartments: implications for multiple sclerosis immunopathology
Profiling of small non-coding RNAs across cellular and biofluid compartments: implications for multiple sclerosis immunopathology
Abstract Multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system (CNS), is associated with dysregulation of microRNAs (miRNA). We here analyzed all classes of small non-coding RNAs (sncRNAs) in matching peripheral blood mononuclear cells (PBMCs), plasma, cerebrospinal fluid (CSF) cells and cell-free CSF from relapsing-remitting (RRMS, n=12 in relapse, n=11 in remission), secondary progressive (SPMS, n=6) MS patients and non-inflammatory and inflammatory neurological disease controls (NINDC, n=11; INDC, n=5). We show widespread changes in small nuclear, nucleolar, transfer RNAs and miRNAs. In CSF cells, 133/133 and 115/117 differentially expressed sncRNAs are increased in RRMS relapse compared to remission and RRMS compared to NINDC, respectively. In contrast, 65/67 differentially expressed PBMC sncRNAs are decreased in RRMS compared to NINDC. The striking contrast between periphery and CNS suggests that sncRNA-mediated mechanisms, including alternative splicing, RNA degradation and mRNA translation, regulate the transcriptome of pathogenic cells primarily in the target organ.
Needhamsen Maria、Ekman Diana、Nimer Faiez Al、Scicluna Patrick、Faridani Omid R、Piehl Fredrik、Jagodic Maja、Zheleznyakova Galina Yurevna、Khademi Mohsen、Hagemann-Jensen Michael、Olsson Tomas、Piket Eliane
Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University HospitalDept of Biochemistry and Biophysics, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Stockholm UniversityDepartment of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital||Center of Neurology, Academic Specialist Center, Stockholm Health ServicesDepartment of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital||Department of Cell and Molecular Biology, Karolinska InstitutetDepartment of Cell and Molecular Biology, Karolinska Institutet||Lowy Cancer Research Centre, School of Medical Sciences, University of New South Wales||Garvan Institute of Medical ResearchDepartment of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital||Center of Neurology, Academic Specialist Center, Stockholm Health ServicesDepartment of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University HospitalDepartment of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University HospitalDepartment of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University HospitalDepartment of Cell and Molecular Biology, Karolinska InstitutetDepartment of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital||Center of Neurology, Academic Specialist Center, Stockholm Health ServicesDepartment of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital
神经病学、精神病学基础医学分子生物学
Needhamsen Maria,Ekman Diana,Nimer Faiez Al,Scicluna Patrick,Faridani Omid R,Piehl Fredrik,Jagodic Maja,Zheleznyakova Galina Yurevna,Khademi Mohsen,Hagemann-Jensen Michael,Olsson Tomas,Piket Eliane.Profiling of small non-coding RNAs across cellular and biofluid compartments: implications for multiple sclerosis immunopathology[EB/OL].(2025-03-28)[2025-08-02].https://www.biorxiv.org/content/10.1101/2020.05.15.097519.点此复制
评论