Functional profile, homing and residency of protective T cell immune responses against SARS-CoV-2
Functional profile, homing and residency of protective T cell immune responses against SARS-CoV-2
SUMMARY To inform on the correlates of protection against SARS-CoV-2, we studied T cell functions, migration patterns and apoptosis associated with antigen responses in three groups of patients during acute infection. T cell functional profiles against SARS-CoV-2 depended on the targeted viral protein and clinical outcome. Hospitalization and disease severity were associated with predominant IFNg and IL-4 responses, as well as increased responses against S peptides and apoptosis, while non-hospitalized patients were characterized by IL-10 secretion, to which a particular subset expressing high levels of CCR7 contributed abundantly. Importantly, lung-resident memory T cells were strongly detected in convalescent patients, in which contemporary blood did not reflect tissue resident profiles. Our results suggest that a balanced anti-inflammatory antiviral response promoted by non-spike proteins may be key to favor infection resolution without major complications. Still, these immune responses can migrate and establish in the lung as resident memory T cells, affecting future protection.
Massana N¨2ria、Grau-Exp¨?sito Judith、Suppi Marina、Astorga-Gamaza Antonio、Perea David、Rosado Joel、Torrella Ariadna、Planas Bibiana、Alvarez-de la Sierra Daniel、Andr¨|s Cristina、Pujol-Borrell Ricardo、Falc¨? Vicen?、Buz¨?n Mar¨aa J.、Genesc¨¤ Meritxell、Almirante Benito、Burgos Joaqu¨an、Ayora Alfonso、Suanzes Paula、Esperalba Juliana、Sansano Irene、Falc¨? Anna、Ram¨?n y Cajal Santiago、Ant¨?n Andr¨|s、Navarro Jordi、S¨￠nchez-Gaona Nerea、Kirkegaard Cristina
Infectious Diseases Department, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129Infectious Diseases Department, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129Infectious Diseases Department, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129Infectious Diseases Department, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129Infectious Diseases Department, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129Thoracic Surgery and Lung Transplantation Department, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital CampusInfectious Diseases Department, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129Infectious Diseases Department, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129Diagnostic Immunology Group, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129Respiratory Viruses Unit, Microbiology Department, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129Diagnostic Immunology Group, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129||FOCIS Center of ExcellenceInfectious Diseases Department, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129Infectious Diseases Department, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129Infectious Diseases Department, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129Infectious Diseases Department, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129Infectious Diseases Department, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129Occupational Risk Prevention Unit, Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129Infectious Diseases Department, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129Respiratory Viruses Unit, Microbiology Department, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129Pathology Department, Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129, 08035 Barcelona, Departament de Ci¨¨ncies morfol¨°giques, Universitat Aut¨°noma de Barcelona, Universitat Aut¨°noma de BarcelonaInfectious Diseases Department, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129Pathology Department, Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129, 08035 Barcelona, Departament de Ci¨¨ncies morfol¨°giques, Universitat Aut¨°noma de Barcelona, Universitat Aut¨°noma de BarcelonaRespiratory Viruses Unit, Microbiology Department, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129Infectious Diseases Department, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129Infectious Diseases Department, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129Infectious Diseases Department, Vall d?ˉHebron Institut de Recerca (VHIR), Vall d?ˉHebron Hospital Universitari, Vall d?ˉHebron Barcelona Hospital Campus, Passeig Vall d?ˉHebron 119-129
基础医学
Massana N¨2ria,Grau-Exp¨?sito Judith,Suppi Marina,Astorga-Gamaza Antonio,Perea David,Rosado Joel,Torrella Ariadna,Planas Bibiana,Alvarez-de la Sierra Daniel,Andr¨|s Cristina,Pujol-Borrell Ricardo,Falc¨? Vicen?,Buz¨?n Mar¨aa J.,Genesc¨¤ Meritxell,Almirante Benito,Burgos Joaqu¨an,Ayora Alfonso,Suanzes Paula,Esperalba Juliana,Sansano Irene,Falc¨? Anna,Ram¨?n y Cajal Santiago,Ant¨?n Andr¨|s,Navarro Jordi,S¨￠nchez-Gaona Nerea,Kirkegaard Cristina.Functional profile, homing and residency of protective T cell immune responses against SARS-CoV-2[EB/OL].(2025-03-28)[2025-05-01].https://www.medrxiv.org/content/10.1101/2020.12.02.20238907.点此复制
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