Durable Humoral and Cellular Immune Responses Following Ad26.COV2.S Vaccination for COVID-19
Durable Humoral and Cellular Immune Responses Following Ad26.COV2.S Vaccination for COVID-19
ABSTRACT Interim immunogenicity and efficacy data for the Ad26.COV2.S vaccine for COVID-19 have recently been reported1-3. We describe here the 8-month durability of humoral and cellular immune responses in 20 individuals who received one or two doses of 5×1010 vp or 1011 vp Ad26.COV2.S and in 5 participants who received placebo2. We evaluated antibody and T cell responses on day 239, which was 8 months after the single-shot vaccine regimen (N=10) or 6 months after the two-shot vaccine regimen (N=10), although the present study was not powered to compare these regimens3. We also report neutralizing antibody responses against the parental SARS-CoV-2 WA1/2020 strain as well as against the SARS-CoV-2 variants D614G, B.1.1.7 (alpha), B.1.617.1 (kappa), B.1.617.2 (delta), P.1 (gamma), B.1.429 (epsilon), and B.1.351 (beta).
Douoguih Macaya、Chang Aiquan、Gebre Makda、McMahan Katherine、de Groot Anne Marit、Heerwegh Dirk、Struyf Frank、van Hoof Johan、Schuitemaker Hanneke、Barouch Dan H.、Sadoff Jerald、Yu Jingyou、Chandrashekar Abishek、Patel Shivani、Liu Jinyan、Gars Mathieu Le、Stephenson Kathryn E.
Janssen Vaccines & PreventionCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical CenterCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical CenterCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical CenterJanssen Vaccines & PreventionJanssen Research & DevelopmentJanssen Research & DevelopmentJanssen Vaccines & PreventionJanssen Vaccines & PreventionCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical CenterJanssen Vaccines & PreventionCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical CenterCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical CenterCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical CenterCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical CenterJanssen Vaccines & PreventionCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center
预防医学基础医学生物科学理论、生物科学方法
Douoguih Macaya,Chang Aiquan,Gebre Makda,McMahan Katherine,de Groot Anne Marit,Heerwegh Dirk,Struyf Frank,van Hoof Johan,Schuitemaker Hanneke,Barouch Dan H.,Sadoff Jerald,Yu Jingyou,Chandrashekar Abishek,Patel Shivani,Liu Jinyan,Gars Mathieu Le,Stephenson Kathryn E..Durable Humoral and Cellular Immune Responses Following Ad26.COV2.S Vaccination for COVID-19[EB/OL].(2025-03-28)[2025-05-05].https://www.medrxiv.org/content/10.1101/2021.07.05.21259918.点此复制
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