nQuire: A statistical framework for ploidy estimation using next generation sequencing
nQuire: A statistical framework for ploidy estimation using next generation sequencing
Abstract SummarynQuire is a statistical framework that distinguishes between diploids, triploids and tetraploids using next generation sequencing. The command-line tool models the distribution of base frequencies at variable sites using a Gaussian Mixture Model, and uses maximum likelihood to select the most plausible ploidy model. Availability and ImplementationThe model is implemented as a stand-alone Linux command line tool in the C programming language and is available at github under the MIT licence. Please also refer to github.com/clwgg/nQuire for usage instructions. Contact: clemens.weiss@tuebingen.mpg.de or hernan.burbano@tuebingen.mpg.de
Wei? Clemens L.、Pais Marina、Cano Liliana M.、Burbano Hern¨￠n A.、Kamoun Sophien
Research Group for Ancient Genomics and Evolution, Department of Molecular Biology, Max Planck Institute for Developmental BiologyThe Sainsbury LaboratoryThe Sainsbury Laboratory||University of Florida, Department of Plant PathologyResearch Group for Ancient Genomics and Evolution, Department of Molecular Biology, Max Planck Institute for Developmental BiologyThe Sainsbury Laboratory
遗传学生物科学研究方法、生物科学研究技术计算技术、计算机技术
Wei? Clemens L.,Pais Marina,Cano Liliana M.,Burbano Hern¨￠n A.,Kamoun Sophien.nQuire: A statistical framework for ploidy estimation using next generation sequencing[EB/OL].(2025-03-28)[2025-05-02].https://www.biorxiv.org/content/10.1101/143537.点此复制
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