Brown Adipose Tissue and Skeletal Muscle Coordinately Contribute to Thermogenesis in Mice
Brown Adipose Tissue and Skeletal Muscle Coordinately Contribute to Thermogenesis in Mice
Abstract Endotherms increase the rate of metabolism in metabolic organs as one strategy to cope with a decline in temperature of the external environment. However, an additional major contributor to maintenance of body temperature in a cold environment is contraction-based thermogenesis in skeletal muscle. Here we show that impairment of hind limb muscle contraction by cast immobilization suppresses skeletal muscle thermogenesis and activates brown adipose tissue (BAT) thermogenesis as a compensatory mechanism. BAT utilizes free branched-chain amino acids (BCAAs) derived from skeletal muscle as an energy substrate for thermogenesis, and interleukin-6 released by skeletal muscle stimulates BCAA production in muscle for support of BAT thermogenesis. Our findings suggest that BAT and skeletal muscle cooperate to maintain body temperature in endotherms.
Tsutsumi Rie、Shiuchi Tetsuya、Taniguchi Momoka、Okamatsu-Ogura Yuko、Kuroda Masashi、Nomura Kazuhiro、Sakaue Hiroshi、Izumi-Mishima Yuna、Yoneshiro Takeshi、Fujimoto Saori
Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate SchoolDepartment of Integrative Physiology, Institute of Biomedical Sciences, Tokushima University Graduate SchoolDepartment of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate SchoolLaboratory of Biochemistry, Faculty of Veterinary Medicine, Hokkaido UniversityDepartment of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate SchoolDepartment of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate SchoolDepartment of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate SchoolDepartment of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate SchoolDivision of Molecular Physiology and Metabolism, Tohoku University Graduate School of MedicineDepartment of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School
生理学生物化学细胞生物学
Tsutsumi Rie,Shiuchi Tetsuya,Taniguchi Momoka,Okamatsu-Ogura Yuko,Kuroda Masashi,Nomura Kazuhiro,Sakaue Hiroshi,Izumi-Mishima Yuna,Yoneshiro Takeshi,Fujimoto Saori.Brown Adipose Tissue and Skeletal Muscle Coordinately Contribute to Thermogenesis in Mice[EB/OL].(2025-03-28)[2025-08-02].https://www.biorxiv.org/content/10.1101/2024.05.26.595945.点此复制
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