ACE2 polymorphisms and individual susceptibility to SARS-CoV-2 infection: insights from an in silico study
ACE2 polymorphisms and individual susceptibility to SARS-CoV-2 infection: insights from an in silico study
Abstract The current SARS covid-19 epidemic spread appears to be influenced by ethnical, geographical and sex-related factors that may involve genetic susceptibility to diseases. Similar to SARS-CoV, SARS-CoV-2 exploits angiotensin-converting enzyme 2 (ACE2) as a receptor to invade cells, notably type II alveolar epithelial cells. Importantly, ACE2 gene is highly polymorphic. Here we have used in silico tools to analyze the possible impact of ACE2 single-nucleotide polymorphisms (SNPs) on the interaction with SARS-CoV-2 spike glycoprotein. We found that S19P (common in African people) and K26R (common in European people) were, among the most diffused SNPs worldwide, the only two SNPs that were able to potentially affect the interaction of ACE2 with SARS-CoV-2 spike. FireDock simulations demonstrated that while S19P may decrease, K26R might increase the ACE2 affinity for SARS-CoV-2 Spike. This finding suggests that the S19P may genetically protect, and K26R may predispose to more severe SARS-CoV-2 disease.
Calcagnile Matteo、Iannelli Antonio、Bucci Cecilia、Forgez Patricia、Alifano Marco、Alifano Pietro
Department of Biological and Environmental Sciences and Technologies, University of SalentoDigestive Disease Department, Archet 2 Hospital, Nice University Hospital, University of Nice C?te d?ˉAzur||INSERM,U1065, Team 8 ?°Hepatic complications of obesity?±, University Nice C?te d?ˉAzurDepartment of Biological and Environmental Sciences and Technologies, University of SalentoINSERM UMR-S 1124 T3S, Eq 5 CELLULAR HOMEOSTASIS, CANCER and THERAPY, University of Paris, Campus Saint GermainThoracic Surgery Department, Cochin Hospital, APHP Centre, University of Paris||INSERM U1138 Team ?Cancer, Immune Control, and Escape?, Cordeliers Research Center, University of ParisDepartment of Biological and Environmental Sciences and Technologies, University of Salento
基础医学生物科学研究方法、生物科学研究技术
Calcagnile Matteo,Iannelli Antonio,Bucci Cecilia,Forgez Patricia,Alifano Marco,Alifano Pietro.ACE2 polymorphisms and individual susceptibility to SARS-CoV-2 infection: insights from an in silico study[EB/OL].(2025-03-28)[2025-08-02].https://www.biorxiv.org/content/10.1101/2020.04.23.057042.点此复制
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