Comparative genomics of ten new Caenorhabditis species
Comparative genomics of ten new Caenorhabditis species
Abstract The nematode Caenorhabditis elegans has been central to the understanding of metazoan biology. However, C. elegans is but one species among millions and the significance of this important model organism will only be fully revealed if it is placed in a rich evolutionary context. Global sampling efforts have led to the discovery of over 50 putative species from the genus Caenorhabditis, many of which await formal species description. Here, we present species descriptions for ten new Caenorhabditis species. We also present draft genome sequences for nine of these new species, along with a transcriptome assembly for one. We exploit these whole-genome data to reconstruct the Caenorhabditis phylogeny and use this phylogenetic tree to dissect the evolution of morphology in the genus. We show unexpected complexity in the evolutionary history of key developmental pathway genes. The genomic data also permit large scale analysis of gene structure, which we find to be highly variable within the genus. These new species and the associated genomic resources will be essential in our attempts to understand the evolutionary origins of the C. elegans model.
Stevens Lewis、F¨|lix Marie-Anne、Beltran Toni、Braendle Christian、Caurcel Carlos、Fausett Sarah、Newton Matt D.、Noble Luke M.、Richaud Aur¨|lien、Sudhaus Walter、Rockman Matthew V.、Fitch David、Kaur Taniya、Kiontke Karin、Fr¨|zal Lise、Blaxter Mark
Institute of Evolutionary Biology, Ashworth Laboratories, School of Biological Sciences, University of EdinburghInstitut de Biologie de l?ˉEcole Normale Sup¨|rieure, Centre National de la Recherche Scientifique, Institut National de la Sant¨| et de la Recherche M¨|dicale, ¨|cole Normale Sup¨|rieure, Paris Sciences et LettresMRC London Institute of Medical SciencesUniversit¨| C?te d?ˉAzur, Centre National de la Recherche Scientifique, Inserm, Institute of Biology ValroseInstitute of Evolutionary Biology, Ashworth Laboratories, School of Biological Sciences, University of EdinburghUniversit¨| C?te d?ˉAzur, Centre National de la Recherche Scientifique, Inserm, Institute of Biology ValroseMRC London Institute of Medical Sciences||Molecular Virology, Department of Medicine, Imperial College LondonCenter for Genomics and Systems Biology, Department of Biology, New York UniversityInstitut de Biologie de l?ˉEcole Normale Sup¨|rieure, Centre National de la Recherche Scientifique, Institut National de la Sant¨| et de la Recherche M¨|dicale, ¨|cole Normale Sup¨|rieure, Paris Sciences et LettresInstitut f¨1r Biologie/Zoologie, Freie Universit?t BerlinCenter for Genomics and Systems Biology, Department of Biology, New York UniversityDepartment of Biology, New York UniversityCenter for Genomics and Systems Biology, Department of Biology, New York UniversityDepartment of Biology, New York UniversityInstitut de Biologie de l?ˉEcole Normale Sup¨|rieure, Centre National de la Recherche Scientifique, Institut National de la Sant¨| et de la Recherche M¨|dicale, ¨|cole Normale Sup¨|rieure, Paris Sciences et LettresInstitute of Evolutionary Biology, Ashworth Laboratories, School of Biological Sciences, University of Edinburgh
遗传学分子生物学动物学
Stevens Lewis,F¨|lix Marie-Anne,Beltran Toni,Braendle Christian,Caurcel Carlos,Fausett Sarah,Newton Matt D.,Noble Luke M.,Richaud Aur¨|lien,Sudhaus Walter,Rockman Matthew V.,Fitch David,Kaur Taniya,Kiontke Karin,Fr¨|zal Lise,Blaxter Mark.Comparative genomics of ten new Caenorhabditis species[EB/OL].(2025-03-28)[2025-08-02].https://www.biorxiv.org/content/10.1101/398446.点此复制
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