Plasmodium infection induces cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein
Plasmodium infection induces cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein
ABSTRACT Individuals with acute malaria infection generated high levels of antibodies that cross-react with the SARS-CoV-2 Spike protein. Cross-reactive antibodies specifically recognized the sialic acid moiety on N-linked glycans of the Spike protein and do not neutralize in vitro SARS-CoV-2. Sero-surveillance is critical for monitoring and projecting disease burden and risk during the pandemic; however, routine use of Spike protein-based assays may overestimate SARS-CoV-2 exposure and population-level immunity in malaria-endemic countries.
Badiane Aida S.、Filler Renata B.、Moukoko Carole Else Eboumbou、Boum Yap II、Ou¨|draogo Jean Bosco、Lapidus Sarah、Huck John D.、Klein Jon、Strine Madison S.、Sy Mouhamad、Dieye Baba、Vigan-Womas In¨|s、Mbengue Alassane、Diagne Moussa M.、Pouye Mariama N.、Faye Rokhaya、Diouf Babacar、Costa Federico、Ben-Mamoun Choukri、Som¨| Fabrice A.、Ndiaye Daouda、Wisnewski Adam、Reis Mitermayer、Muenker M. Catherine、Hodson Daniel Z.、Campbell Melissa、Faye Ousmane、Sall Amadou Alpha、Parikh Sunil、Diagne Cheikh Tidiane、Cappello Michael、Wilen Craig B.、Moore Adam J.、Ko Albert I.、Bei Amy K.、Dabir¨| Roch K.、Mbaye Amadou Moctar、V¨|lez Juan Carlos Quintero、Casanovas-Massana Arnau、Dai Yile、Baum-Jones Elisabeth、Deme Awa B.、Diallo Fatoumata、Liu Feimei、Diedhiou Younous、Nery Nivison Jr、Andrews Jason R.、Kamath Kathy、Iwasaki Akiko、Shon John、Srivathsan Ariktha、Sadio Bacary D.、Wilson Michael、Katz Ben Z.、Lucas Carolina、Ndiaye Ibrahima Mbaye、Ring Aaron M.、Sene Seynabou D.、Mbarga Yannick、Mangou Khadidiatou
Cheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and MycologyYale School of Medicine, Department of Immunobiology||Yale School of Medicine, Department of Laboratory MedicineDepartment of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala||Malaria Research Unit, Center Pasteur CameroonUniversity of Yaound¨| and EpicentreInstitut de Recherche en Sciences de La Sant¨| (IRSS)/Centre MurazYale School of Public Health, Department of Epidemiology of Microbial DiseasesYale School of Medicine, Department of ImmunobiologyYale School of Medicine, Department of ImmunobiologyYale School of Medicine, Department of Immunobiology||Yale School of Medicine, Department of Laboratory MedicineCheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and MycologyCheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and MycologyP?le Immunophysiopathologie et Maladies InfectieusesG4 - Malaria Experimental Genetic Approaches & Vaccines, P?le Immunophysiopathologie et Maladies InfectieusesP?le Virologie, Institut Pasteur de DakarG4 - Malaria Experimental Genetic Approaches & Vaccines, P?le Immunophysiopathologie et Maladies InfectieusesP?le Immunophysiopathologie et Maladies InfectieusesP?le Immunophysiopathologie et Maladies InfectieusesYale School of Public Health, Department of Epidemiology of Microbial Diseases||Instituto de Sa¨2de Coletiva, Universidade Federal da Bahia||Instituto Gon?alo Moniz, Funda??o Oswaldo Cruz, Minist¨|rio da Sa¨2deDepartment of Internal Medicine, Section of Infectious DiseasesInstitut de Recherche en Sciences de La Sant¨| (IRSS)/Centre MurazCheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and MycologyYale Occupational and Environmental Medicine Program, Department of Internal Medicine, Yale School of MedicineYale School of Public Health, Department of Epidemiology of Microbial Diseases||Instituto de Sa¨2de Coletiva, Universidade Federal da Bahia||Instituto Gon?alo Moniz, Funda??o Oswaldo Cruz, Minist¨|rio da Sa¨2deYale School of Public Health, Department of Epidemiology of Microbial DiseasesYale School of Public Health, Department of Epidemiology of Microbial DiseasesYale Center for Clinical Investigation, Yale School of MedicineP?le Virologie, Institut Pasteur de DakarP?le Virologie, Institut Pasteur de DakarYale School of Public Health, Department of Epidemiology of Microbial DiseasesDiaTROPIX Rapid Diagnostic Tests Facility, Institut Pasteur de DakarDepartment of Pediatrics, Yale School of MedicineYale School of Medicine, Department of ImmunobiologyYale School of Public Health, Department of Epidemiology of Microbial DiseasesYale School of Public Health, Department of Epidemiology of Microbial Diseases||Instituto Gon?alo Moniz, Funda??o Oswaldo Cruz, Minist¨|rio da Sa¨2deYale School of Public Health, Department of Epidemiology of Microbial Diseases||Cheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and Mycology||G4 - Malaria Experimental Genetic Approaches & Vaccines, P?le Immunophysiopathologie et Maladies InfectieusesInstitut de Recherche en Sciences de La Sant¨| (IRSS)/Centre MurazCheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and MycologyGrupo de Investigaci¨?n Ciencias Veterinarias Centauro, Universidad de Antioquia||Grupo de Investigaci¨?n Ciencias Veterinarias Centauro, University of Antioquia||Grupo de Investigaci¨?n Microbiolog¨aa B¨￠sica y Aplicada, University of AntioquiaYale School of Public Health, Department of Epidemiology of Microbial DiseasesYale School of Medicine, Department of ImmunobiologySerimmune, Inc.Cheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and MycologyG4 - Malaria Experimental Genetic Approaches & Vaccines, P?le Immunophysiopathologie et Maladies InfectieusesYale School of Medicine, Department of ImmunobiologyCheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and MycologyInstituto de Sa¨2de Coletiva, Universidade Federal da Bahia||Instituto Gon?alo Moniz, Funda??o Oswaldo Cruz, Minist¨|rio da Sa¨2deDivision of Infectious Diseases and Geographic Medicine, School of Medicine, Stanford UniversitySerimmune, Inc.Yale School of Medicine, Department of ImmunobiologySerimmune, Inc.Yale School of Public Health, Department of Epidemiology of Microbial DiseasesP?le Virologie, Institut Pasteur de DakarDepartment of Parasitology, Noguchi Memorial Institute for Medical Research, University of GhanaDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Division of Infectious DiseasesYale School of Medicine, Department of ImmunobiologyCheikh Anta Diop University, Aristide le Dantec Hospital, Laboratory of Parasitology and MycologyYale School of Medicine, Department of ImmunobiologyG4 - Malaria Experimental Genetic Approaches & Vaccines, P?le Immunophysiopathologie et Maladies InfectieusesDouala Military HospitalG4 - Malaria Experimental Genetic Approaches & Vaccines, P?le Immunophysiopathologie et Maladies Infectieuses
基础医学微生物学分子生物学
Badiane Aida S.,Filler Renata B.,Moukoko Carole Else Eboumbou,Boum Yap II,Ou¨|draogo Jean Bosco,Lapidus Sarah,Huck John D.,Klein Jon,Strine Madison S.,Sy Mouhamad,Dieye Baba,Vigan-Womas In¨|s,Mbengue Alassane,Diagne Moussa M.,Pouye Mariama N.,Faye Rokhaya,Diouf Babacar,Costa Federico,Ben-Mamoun Choukri,Som¨| Fabrice A.,Ndiaye Daouda,Wisnewski Adam,Reis Mitermayer,Muenker M. Catherine,Hodson Daniel Z.,Campbell Melissa,Faye Ousmane,Sall Amadou Alpha,Parikh Sunil,Diagne Cheikh Tidiane,Cappello Michael,Wilen Craig B.,Moore Adam J.,Ko Albert I.,Bei Amy K.,Dabir¨| Roch K.,Mbaye Amadou Moctar,V¨|lez Juan Carlos Quintero,Casanovas-Massana Arnau,Dai Yile,Baum-Jones Elisabeth,Deme Awa B.,Diallo Fatoumata,Liu Feimei,Diedhiou Younous,Nery Nivison Jr,Andrews Jason R.,Kamath Kathy,Iwasaki Akiko,Shon John,Srivathsan Ariktha,Sadio Bacary D.,Wilson Michael,Katz Ben Z.,Lucas Carolina,Ndiaye Ibrahima Mbaye,Ring Aaron M.,Sene Seynabou D.,Mbarga Yannick,Mangou Khadidiatou.Plasmodium infection induces cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein[EB/OL].(2025-03-28)[2025-06-17].https://www.medrxiv.org/content/10.1101/2021.05.10.21256855.点此复制
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