Bowel Colonization by Non-Commensal Fungi in Neonatal Obstructive Cholangitis and Biliary Atresia
Bowel Colonization by Non-Commensal Fungi in Neonatal Obstructive Cholangitis and Biliary Atresia
Abstract Up to two-thirds of biliary atresia (BA) patients need liver transplantation after the standard Kasai portoenterostomy treatment. Unrelenting cholangitis often precedes the full-blown presentation of BA. Using ribosomal 18S sequencing, here we report bowel colonization by non-commensal Aspergillus fungi in one case of neonatal obstructive cholangitis. Continuous oral fluconazole treatment resolved obstructive cholangitis completely. Colonization by non-commensal Aspergillus and Cerrena were additionally identified in 2 BA cases. In brief, bowel colonization by non-commensal fungi could be a treatable cause of neonatal obstructive cholangitis and potentially BA at an early stage.
Liu Hong-Hsing、Lin Chia-Ray、Chang Ya-Hui、Huang Song-Wei、Chen Huey-Ling、Ni Yen-Hsuan
Institute of Molecular and Genomic Medicine, National Health Research Institutes||Pediatrics, En Chu Kong HospitalPediatrics Department, National Taiwan University Children?ˉs HospitalInstitute of Molecular and Genomic Medicine, National Health Research InstitutesInstitute of Molecular and Genomic Medicine, National Health Research InstitutesPediatrics Department, National Taiwan University Children?ˉs HospitalPediatrics Department, National Taiwan University Children?ˉs Hospital
基础医学微生物学儿科学
Liu Hong-Hsing,Lin Chia-Ray,Chang Ya-Hui,Huang Song-Wei,Chen Huey-Ling,Ni Yen-Hsuan.Bowel Colonization by Non-Commensal Fungi in Neonatal Obstructive Cholangitis and Biliary Atresia[EB/OL].(2025-03-28)[2025-05-02].https://www.medrxiv.org/content/10.1101/2023.03.09.23287026.点此复制
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