The photobiology of the human circadian clock
The photobiology of the human circadian clock
Abstract In modern society, the widespread use of artificial light at night disrupts the suprachiasmatic nucleus (SCN), which serves as our central circadian clock. Existing models describe excitatory responses of the SCN to primarily blue light, but direct measures in humans are absent. The combination of state-of-the-art neuroimaging techniques and custom-made MRI compatible LED devices allowed to directly measure the light response of the SCN. In contrast to the general expectation, we found that SCN activity was suppressed by light. The suppressions were observed not only in response to narrowband blue light (λmax: 470nm) but remarkably, also in response to green (λmax: 515nm) and orange (λmax: 590nm), but not to violet light (λmax: 405nm). The broadband sensitivity of the SCN implies that strategies on light exposure should be revised: enhancement of light levels during daytime is possible with wavelengths other than blue, while during nighttime, all colors are potentially disruptive.
Janse Jan A.M.、Swaab Dick F.、Meijer Johanna H.、Schoonderwoerd Robin A.、Hirschler Lydiane、van Berloo Sander、de Rover Mischa、van Osch Matthias J.P.、Klop Ilse、Scholten Leonie、Willemse Channa R.
Department of Neurophysiology, Leiden University Medical CenterDepartment of Neuropsychiatric Disorders, Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and SciencesDepartment of Neurophysiology, Leiden University Medical CenterDepartment of Neurophysiology, Leiden University Medical CenterDepartment of Radiology, C.J. Gorter Center for High Field MRI, Leiden University Medical CenterDepartment of Medical Technology, Leiden University Medical CenterDepartment of Neurophysiology, Leiden University Medical Center||Department of Clinical Psychology, Institute of Psychology, Leiden UniversityDepartment of Radiology, C.J. Gorter Center for High Field MRI, Leiden University Medical CenterDepartment of Neurophysiology, Leiden University Medical CenterDepartment of Neurophysiology, Leiden University Medical CenterDepartment of Neurophysiology, Leiden University Medical Center
生物科学现状、生物科学发展生理学生物科学研究方法、生物科学研究技术
Janse Jan A.M.,Swaab Dick F.,Meijer Johanna H.,Schoonderwoerd Robin A.,Hirschler Lydiane,van Berloo Sander,de Rover Mischa,van Osch Matthias J.P.,Klop Ilse,Scholten Leonie,Willemse Channa R..The photobiology of the human circadian clock[EB/OL].(2025-03-28)[2025-05-24].https://www.biorxiv.org/content/10.1101/2021.10.13.463655.点此复制
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