Sex, racial, and APOE -ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer’s disease
Sex, racial, and APOE -ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer’s disease
Structured Abstract INTRODUCTIONThe effects of sex, race, and Apolipoprotein E (APOE) – Alzheimer’s disease (AD) risk factors – on white matter integrity are not well characterized.METHODSDiffusion MRI data from nine well-established longitudinal cohorts of aging were free-water (FW)-corrected and harmonized. This dataset included 4,702 participants (age=73.06 ± 9.75) with 9,671 imaging sessions over time. FW and FW-corrected fractional anisotropy (FAFWcorr) were used to assess differences in white matter microstructure by sex, race, and APOE-ε4 carrier status.RESULTSSex differences in FAFWcorr in association and projection tracts, racial differences in FAFWcorr in projection tracts, and APOE-ε4 differences in FW limbic and occipital transcallosal tracts were most pronounced.DISCUSSIONThere are prominent differences in white matter microstructure by sex, race, and APOE- ε4 carrier status. This work adds to our understanding of disparities in AD. Additional work to understand the etiology of these differences is warranted.HighlightsSex, race, and APOE-ε4 carrier status relate to white matter microstructural integrityFemales generally have lower FAFWcorr compared to malesNon-Hispanic Black adults generally have lower FAFWcorr than non-Hispanic White adultsAPOE-ε4 carriers tended to have higher FW than non-carriersResearch in ContextSystematic ReviewThe authors used PubMed and Google Scholar to review literature that used conventional and free-water (FW)-corrected microstructural metrics to evaluate sex, race, and APOE-ε4 differences in white matter microstructure. While studies have previously explored differences by sex and APOE-ε4 status, less is known about racial differences and no large-scale FW-corrected analysis has been performed.InterpretationSex and race were more associated with FAFWcorr while APOE-ε4 status was associated with FW metrics. Association, projection, limbic, and occipital transcallosal tracts showed the greatest differences.Future DirectionFuture studies to determine the biological and social pathways that lead to sex, racial, and APOE-ε4 differences are warranted. Consent StatementAll participants provided informed consent in their respective cohort studies.
Mormino Elizabeth C.、Alzheimer?ˉs Disease Neuroimaging Initiative (ADNI)、The BIOCARD Study Team、Biber Sarah A.、Dumitrescu Logan、Risacher Shannon L.、Barnes Lisa L.、Bennett David A.、Jefferson Angela L.、Resnick Susan M.、Hohman Timothy J.、An Yang、Arfanakis Konstantinos、Erus Guray、Peterson Amalia、Zaras Dimitrios、Yang Yisu、Deters Kacie D.、Pechman Kimberly R.、Gao Chenyu、Khairi Nazirah Mohd、The Alzheimer?ˉs Disease Sequencing Project (ADSP)、Johnson Sterling C.、Archer Derek B.、Li Zhiyuan、Thompson Paul M.、Schilling Kurt、Beason-Held Lori L.、Toga Arthur W.、Saykin Andrew J.、Wilson Jo Ellen、Albert Marilyn、Yao Tianyuan、Landman Bennett A.、Shashikumar Niranjana、Sathe Aditi、Davatzikos Christos、Schneider Julie、Kim Michael E.、Tosun Duygu、Cambronero Francis、Durant Alaina、Zhang Panpan、Kukull Walter、Huo Yuankai、Gifford Katherine A.
Department of Neurology and Neurological Sciences, Stanford University School of MedicineNational Alzheimer?ˉs Coordinating Center, University of WashingtonVanderbilt Memory and Alzheimer?ˉs Center, Vanderbilt University School of Medicine||Department of Neurology, Vanderbilt University Medical Center||Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN||Vanderbilt Brain Institute, Vanderbilt University Medical CenterDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine||Indiana Alzheimer?ˉs Disease Research Center, Indiana University School of MedicineRush Alzheimer?ˉs Disease Center, Rush University Medical CenterRush Alzheimer?ˉs Disease Center, Rush University Medical CenterVanderbilt Memory and Alzheimer?ˉs Center, Vanderbilt University School of Medicine||Department of Neurology, Vanderbilt University Medical Center||Department of Computer Science, Vanderbilt UniversityLaboratory for Behavioral Neuroscience, National Institute on Aging, National Institutes of HealthVanderbilt Memory and Alzheimer?ˉs Center, Vanderbilt University School of Medicine||Department of Neurology, Vanderbilt University Medical Center||Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN||Vanderbilt Brain Institute, Vanderbilt University Medical CenterLaboratory for Behavioral Neuroscience, National Institute on Aging, National Institutes of HealthDepartment of Biomedical Engineering, Illinois Institute of Technology||Rush Alzheimer?ˉs Disease Center, Rush University Medical Center||Department of Diagnostic Radiology, Rush University Medical CenterDepartment of Radiology, University of PennsylvaniaVanderbilt Memory and Alzheimer?ˉs Center, Vanderbilt University School of Medicine||Department of Neurology, Vanderbilt University Medical CenterVanderbilt Memory and Alzheimer?ˉs Center, Vanderbilt University School of MedicineVanderbilt Memory and Alzheimer?ˉs Center, Vanderbilt University School of MedicineDepartment of Integrative Biology and Physiology, University of CaliforniaVanderbilt Memory and Alzheimer?ˉs Center, Vanderbilt University School of MedicineDepartment of Electrical and Computer Engineering, Vanderbilt University, NashvilleDepartment of Electrical and Computer Engineering, Vanderbilt University, NashvilleWisconsin Alzheimer?ˉs Disease Research Center, School of Medicine and Public Health, University of Wisconsin||Wisconsin Alzheimer?ˉs Institute, School of Medicine and Public Health, University of WisconsinVanderbilt Memory and Alzheimer?ˉs Center, Vanderbilt University School of Medicine||Department of Neurology, Vanderbilt University Medical Center||Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN||Vanderbilt Brain Institute, Vanderbilt University Medical CenterDepartment of Electrical and Computer Engineering, Vanderbilt University, NashvilleImaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern CaliforniaDepartment of Radiology & Radiological Sciences, Vanderbilt University Medical Center||Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical CenterLaboratory for Behavioral Neuroscience, National Institute on Aging, National Institutes of HealthLaboratory of Neuroimaging, USC Stevens Institute of Neuroimaging and Informatics, Keck School of Medicine, University of Southern CaliforniaDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine||Indiana Alzheimer?ˉs Disease Research Center, Indiana University School of MedicineVanderbilt Memory and Alzheimer?ˉs Center, Vanderbilt University School of Medicine||Center for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center||Veteran?ˉs Affairs, Geriatric Research, Education and Clinical Center, Tennessee Valley Healthcare SystemDepartment of Neurology, Johns Hopkins School of Medicine BaltimoreDepartment of Computer Science, Vanderbilt UniversityDepartment of Neurology, Vanderbilt University Medical Center||Department of Computer Science, Vanderbilt University||Department of Electrical and Computer Engineering, Vanderbilt University, Nashville||Vanderbilt Brain Institute, Vanderbilt University Medical Center||Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center||Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center||Department of Biomedical Engineering, Vanderbilt UniversityVanderbilt Memory and Alzheimer?ˉs Center, Vanderbilt University School of MedicineVanderbilt Memory and Alzheimer?ˉs Center, Vanderbilt University School of MedicineDepartment of Radiology, University of PennsylvaniaRush Alzheimer?ˉs Disease Center, Rush University Medical CenterDepartment of Computer Science, Vanderbilt UniversityDepartment of Radiology and Biomedical Imaging, University of California San FranciscoVanderbilt Memory and Alzheimer?ˉs Center, Vanderbilt University School of MedicineVanderbilt Memory and Alzheimer?ˉs Center, Vanderbilt University School of MedicineVanderbilt Memory and Alzheimer?ˉs Center, Vanderbilt University School of Medicine||Department of Biostatistics, Vanderbilt University Medical CenterNational Alzheimer?ˉs Coordinating Center, University of WashingtonDepartment of Computer Science, Vanderbilt University||Department of Electrical and Computer Engineering, Vanderbilt University, NashvilleVanderbilt Memory and Alzheimer?ˉs Center, Vanderbilt University School of Medicine||Department of Neurology, Vanderbilt University Medical Center
神经病学、精神病学基础医学医学研究方法
Mormino Elizabeth C.,Alzheimer?ˉs Disease Neuroimaging Initiative (ADNI),The BIOCARD Study Team,Biber Sarah A.,Dumitrescu Logan,Risacher Shannon L.,Barnes Lisa L.,Bennett David A.,Jefferson Angela L.,Resnick Susan M.,Hohman Timothy J.,An Yang,Arfanakis Konstantinos,Erus Guray,Peterson Amalia,Zaras Dimitrios,Yang Yisu,Deters Kacie D.,Pechman Kimberly R.,Gao Chenyu,Khairi Nazirah Mohd,The Alzheimer?ˉs Disease Sequencing Project (ADSP),Johnson Sterling C.,Archer Derek B.,Li Zhiyuan,Thompson Paul M.,Schilling Kurt,Beason-Held Lori L.,Toga Arthur W.,Saykin Andrew J.,Wilson Jo Ellen,Albert Marilyn,Yao Tianyuan,Landman Bennett A.,Shashikumar Niranjana,Sathe Aditi,Davatzikos Christos,Schneider Julie,Kim Michael E.,Tosun Duygu,Cambronero Francis,Durant Alaina,Zhang Panpan,Kukull Walter,Huo Yuankai,Gifford Katherine A..Sex, racial, and APOE -ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer’s disease[EB/OL].(2025-03-28)[2025-05-09].https://www.biorxiv.org/content/10.1101/2024.06.10.598357.点此复制
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