Neural circuitry for maternal oxytocin release induced by infant cries
Neural circuitry for maternal oxytocin release induced by infant cries
Abstract Oxytocin is a neuropeptide important for maternal physiology and childcare, including parturition and milk ejection during nursing1–8. Suckling triggers oxytocin release, but other sensory cues- specifically infant cries- can elevate oxytocin levels in new human mothers9–11 indicating that cries can activate hypothalamic oxytocin neurons. Here we describe a neural circuit routing auditory information about infant vocalizations to mouse oxytocin neurons. We performed in vivo electrophysiological recordings and photometry from identified oxytocin neurons in awake maternal mice presented with pup calls. We found that oxytocin neurons responded to pup vocalizations, but not pure tones, via input from the posterior intralaminar thalamus, and repetitive thalamic stimulation induced lasting disinhibition of oxytocin neurons. This circuit gates central oxytocin release and maternal behavior in response to calls, providing a mechanism for the integration of sensory cues from the offspring in maternal endocrine networks to ensure modulation of brain state for efficient parenting.
Jung Kanghoon、Bair-Marshall Chloe J.、Martin Kathleen A.、Issa Habon A.、Valtcheva Silvana、Zhang Yiyao、Froemke Robert C.、Kwon Hyung-Bae
Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of MedicineSkirball Institute for Biomolecular Medicine, New York University School of Medicine||Neuroscience Institute, New York University School of Medicine||Department of Otolaryngology, New York University School of Medicine||Department of Neuroscience and Physiology, New York University School of Medicine||Center for Neural Science, New York UniversitySkirball Institute for Biomolecular Medicine, New York University School of Medicine||Neuroscience Institute, New York University School of Medicine||Department of Otolaryngology, New York University School of Medicine||Department of Neuroscience and Physiology, New York University School of Medicine||Center for Neural Science, New York UniversitySkirball Institute for Biomolecular Medicine, New York University School of Medicine||Neuroscience Institute, New York University School of Medicine||Department of Otolaryngology, New York University School of Medicine||Department of Neuroscience and Physiology, New York University School of Medicine||Center for Neural Science, New York UniversitySkirball Institute for Biomolecular Medicine, New York University School of Medicine||Neuroscience Institute, New York University School of Medicine||Department of Otolaryngology, New York University School of Medicine||Department of Neuroscience and Physiology, New York University School of Medicine||Center for Neural Science, New York UniversityNeuroscience Institute, New York University School of MedicineSkirball Institute for Biomolecular Medicine, New York University School of Medicine||Neuroscience Institute, New York University School of Medicine||Department of Otolaryngology, New York University School of Medicine||Department of Neuroscience and Physiology, New York University School of Medicine||Center for Neural Science, New York UniversitySolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine
基础医学神经病学、精神病学生理学
Jung Kanghoon,Bair-Marshall Chloe J.,Martin Kathleen A.,Issa Habon A.,Valtcheva Silvana,Zhang Yiyao,Froemke Robert C.,Kwon Hyung-Bae.Neural circuitry for maternal oxytocin release induced by infant cries[EB/OL].(2025-03-28)[2025-05-01].https://www.biorxiv.org/content/10.1101/2021.03.25.436883.点此复制
评论