Updated Database and Evolutionary Dynamics of U12-Type Introns
Updated Database and Evolutionary Dynamics of U12-Type Introns
ABSTRACT During nuclear maturation of most eukaryotic pre-messenger RNAs and long non-coding RNAs, introns are removed through the process of RNA splicing. Different classes of introns are excised by the U2-type or the U12-type spliceosomes, large complexes of small nuclear ribonucleoprotein particles and associated proteins. We created intronIC, a program for assigning intron class to all introns in a given genome, and used it on 24 eukaryotic genomes to create the Intron Annotation and Orthology Database (IAOD). We then used the data in the IAOD to revisit several hypotheses concerning the evolution of the two classes of spliceosomal introns, finding support for the class conversion model explaining the low abundance of U12-type introns in modern genomes.
Larue Graham E.、Roy Scott W.、Padgett Richard A.、Moyer Devlin C.、Hershberger Courtney E.
Department of Molecular and Cell Biology, University of CaliforniaDepartment of Biology, San Francisco State UniversityDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic and Department of Molecular Medicine, Case Western Reserve UniversityDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic and Department of Molecular Medicine, Case Western Reserve UniversityDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic and Department of Molecular Medicine, Case Western Reserve University
生物科学现状、生物科学发展生物科学研究方法、生物科学研究技术生物科学理论、生物科学方法
Larue Graham E.,Roy Scott W.,Padgett Richard A.,Moyer Devlin C.,Hershberger Courtney E..Updated Database and Evolutionary Dynamics of U12-Type Introns[EB/OL].(2025-03-28)[2025-04-27].https://www.biorxiv.org/content/10.1101/620658.点此复制
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