Simultaneous functional MRI of socially interacting marmosets
Simultaneous functional MRI of socially interacting marmosets
Abstract Social cognition is a dynamic process that requires the perception and integration of a complex set of idiosyncratic features between interacting conspecifics. Here we present a method for simultaneously measuring the whole-brain activation of two socially interacting marmoset monkeys using functional magnetic resonance imaging. MRI hardware (a radiofrequency coil and peripheral devices) and image-processing pipelines were developed to assess brain responses to socialization, both on an intra-brain and inter-brain level. Notably, brain-activation maps acquired during constant interaction demonstrated neuronal synchrony between marmosets in regions of the brain responsible for processing social interaction. This method enables a wide range of possibilities for studying social function and dysfunction in a non-human primate model, including using transgenic models of neuropsychiatric disorders.
Cl¨|ry Justine C.、Mashkovtsev Alexander、Zeman Peter、Everling Stefan、Gati Joseph S.、Gilbert Kyle M.、Schaeffer David J.、Hori Yuki、Menon Ravi S.
Centre for Functional and Metabolic Mapping, The University of Western OntarioCentre for Functional and Metabolic Mapping, The University of Western OntarioCentre for Functional and Metabolic Mapping, The University of Western OntarioCentre for Functional and Metabolic Mapping, The University of Western Ontario||Department of Physiology and Pharmacology, The University of Western OntarioCentre for Functional and Metabolic Mapping, The University of Western Ontario||Department of Medical Biophysics, The University of Western OntarioCentre for Functional and Metabolic Mapping, The University of Western Ontario||Department of Medical Biophysics, The University of Western OntarioDepartment of Neurobiology, University of PittsburghCentre for Functional and Metabolic Mapping, The University of Western OntarioCentre for Functional and Metabolic Mapping, The University of Western Ontario||Department of Medical Biophysics, The University of Western Ontario
生物科学研究方法、生物科学研究技术神经病学、精神病学基础医学
Cl¨|ry Justine C.,Mashkovtsev Alexander,Zeman Peter,Everling Stefan,Gati Joseph S.,Gilbert Kyle M.,Schaeffer David J.,Hori Yuki,Menon Ravi S..Simultaneous functional MRI of socially interacting marmosets[EB/OL].(2025-03-28)[2025-05-08].https://www.biorxiv.org/content/10.1101/2021.02.08.430294.点此复制
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