The most developmentally truncated fishes show extensive Hox gene loss and miniaturized genomes
The most developmentally truncated fishes show extensive Hox gene loss and miniaturized genomes
Abstract Hox genes play a fundamental role in regulating the embryonic development of all animals. Manipulation of these transcription factors in model organisms has unraveled key aspects of evolution, like the transition from fin to limb. However, by virtue of their fundamental role and pleiotropic effects, simultaneous knockouts of several of these genes pose significant challenges. Here, we report on evolutionary simplification in two species of the dwarf minnow genus Paedocypris using whole genome sequencing. The two species feature unprecedented Hox gene loss and genome reduction in association with their massive developmental truncation. We also show how other genes involved in the development of musculature, nervous system, and skeleton have been lost in Paedocypris, mirroring its highly progenetic phenotype. Further, we identify two mechanisms responsible for genome streamlining: severe intron shortening and reduced repeat content. As a naturally simplified system closely related to zebrafish, Paedocypris provides novel insights into vertebrate development.
Matschiner Michael、Hadiaty Renny K.、R¨1ber Lukas、T?rresen Ole K.、Tan Heok H.、Malmstr?m Martin、Jakobsen Kjetill S.、Yaakob Norsham、Britz Ralf、Salzburger Walter
Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biosciences, University of Oslo||Zoological Institute, University of BaselMuseum Zoologicum Bogoriense, Research Center for Biology, Indonesian Institute of SciencesNaturhistorisches Museum der Burgergemeinde Bern||Institute of Ecology and Evolution, University of BernCentre for Ecological and Evolutionary Synthesis (CEES), Department of Biosciences, University of OsloLee Kong Chian Natural History Museum, National University of SingaporeCentre for Ecological and Evolutionary Synthesis (CEES), Department of Biosciences, University of Oslo||Zoological Institute, University of BaselCentre for Ecological and Evolutionary Synthesis (CEES), Department of Biosciences, University of OsloForest Research Institute MalaysiaDepartment of Life Sciences, Natural History MuseumCentre for Ecological and Evolutionary Synthesis (CEES), Department of Biosciences, University of Oslo||Zoological Institute, University of Basel
遗传学动物学分子生物学
Matschiner Michael,Hadiaty Renny K.,R¨1ber Lukas,T?rresen Ole K.,Tan Heok H.,Malmstr?m Martin,Jakobsen Kjetill S.,Yaakob Norsham,Britz Ralf,Salzburger Walter.The most developmentally truncated fishes show extensive Hox gene loss and miniaturized genomes[EB/OL].(2025-03-28)[2025-05-21].https://www.biorxiv.org/content/10.1101/160168.点此复制
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